Alice Y Matoba1. 1. Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA. amatoba@bcm.edu
Abstract
PURPOSE: To report 5 cases of culture-proven fungal keratitis that resolved with moxifloxacin monotherapy. METHODS: Case reports and review of medical literature. Five patients with fungal keratitis were treated with topical moxifloxacin. RESULTS: All 5 patients had resolution of their infection with topical moxifloxacin monotherapy. CONCLUSIONS: Topical fluoroquinolone agents may have significant antifungal properties. However, the vast majority of fungal keratitis patients cannot be cured with fluoroquinolone monotherapy. An initial response of keratitis to topical fluoroquinolone therapy should not lead to the assumption that the infection is bacterial because the possibility of fungal infection cannot be ruled out on that basis.
PURPOSE: To report 5 cases of culture-proven fungal keratitis that resolved with moxifloxacin monotherapy. METHODS: Case reports and review of medical literature. Five patients with fungal keratitis were treated with topical moxifloxacin. RESULTS: All 5 patients had resolution of their infection with topical moxifloxacin monotherapy. CONCLUSIONS: Topical fluoroquinolone agents may have significant antifungal properties. However, the vast majority of fungal keratitispatients cannot be cured with fluoroquinolone monotherapy. An initial response of keratitis to topical fluoroquinolone therapy should not lead to the assumption that the infection is bacterial because the possibility of fungal infection cannot be ruled out on that basis.
Authors: Wei-Boon Khor; Tin Aung; Seang-Mei Saw; Tien-Yin Wong; Paul A Tambyah; Ai-Ling Tan; Roger Beuerman; Li Lim; Wing-Kwong Chan; Wee-Jin Heng; Jimmy Lim; Raymond S K Loh; Sao-Bing Lee; Donald T H Tan Journal: JAMA Date: 2006-06-28 Impact factor: 56.272
Authors: Wuqaas M Munir; Steven I Rosenfeld; Ira Udell; Darlene Miller; Carol L Karp; Eduardo C Alfonso Journal: Cornea Date: 2007-06 Impact factor: 2.651