Literature DB >> 329205

Characterization and localization of the human genes for ribosomal ribonucleic acid.

R D Schmickel, M Knoller.   

Abstract

The genetic sequence complementary to ribosomal RNA was separated from human DNA and its characteristics studied. Both 18S and 28S sequences were located on the same isolated strand. DNA-rRNA hybrids have a melting temperature of 80 degrees or 4 degrees less than that of native ribosomal DNA. Ribosomal genes behave as a satellite when complexed with Ag+ in the Cs2SO4 gradient. With in situ hybridization, these rRNA genes can be shown to chromosomally translocate. The study of a highly fluorescent chromosome indicates that the ribosomal DNA does not contribute to the fluorescent nature of the secondary constrictions. This study examines the molecular organization of human ribosomal genes. The chromosomal inheritance of these genes is explored by in situ hybridization.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 329205     DOI： 10.1203/00006450-197708000-00015

Source DB:  PubMed          Journal:  Pediatr Res        ISSN： 0031-3998            Impact factor:   3.756


  12 in total

1.  Analysis of DNA restriction fragments greater than 5.7 Mb in size from the centromeric region of human chromosomes.

Authors:  P H Arn; X Li; C Smith; M Hsu; D C Schwartz; E W Jabs
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

2.  Nucleoli, nucleolar chromosomes and ribosomal genes in the human spermatocyte.

Authors:  A Stahl; F Wachtler; M Hartung; M Devictor; C Schöfer; W Mosgöller; A de Lanversin; C Fouet; H G Schwarzacher
Journal:  Chromosoma       Date:  1991-12       Impact factor: 4.316

3.  A molecular basis for discrete size variation in human ribosomal DNA.

Authors:  J M Erickson; R D Schmickel
Journal:  Am J Hum Genet       Date:  1985-03       Impact factor: 11.025

4.  Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

Authors:  M L Van Keuren; P C Watkins; H A Drabkin; E W Jabs; J F Gusella; D Patterson
Journal:  Am J Hum Genet       Date:  1986-06       Impact factor: 11.025

5.  Molecular analysis of cloned human 18S ribosomal DNA segments.

Authors:  G N Wilson; B A Hollar; J R Waterson; R D Schmickel
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

6.  Structure and variation of human ribosomal DNA: the external transcribed spacer and adjacent regions.

Authors:  G N Wilson; L L Szura; C Rushford; D Jackson; J Erickson
Journal:  Am J Hum Genet       Date:  1982-01       Impact factor: 11.025

Review 7.  Nucleus-driven mutations of human mitochondrial DNA.

Authors:  M Zeviani
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

8.  Genomic architecture and inheritance of human ribosomal RNA gene clusters.

Authors:  Dawn M Stults; Michael W Killen; Heather H Pierce; Andrew J Pierce
Journal:  Genome Res       Date:  2007-11-19       Impact factor: 9.043

Review 9.  The role of cytologic NOR variants in the etiology of trisomy 21.

Authors:  N B Spinner; D L Eunpu; R D Schmickel; E H Zackai; D McEldrew; G R Bunin; H McDermid; B S Emanuel
Journal:  Am J Hum Genet       Date:  1989-05       Impact factor: 11.025

10.  mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.

Authors:  C T Moraes; S Shanske; H J Tritschler; J R Aprille; F Andreetta; E Bonilla; E A Schon; S DiMauro
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.