Srishti Shrestha1, Christine G Parks1, David M Umbach2, Marie Richards-Barber3, Jonathan N Hofmann4, Honglei Chen5, Aaron Blair4, Laura E Beane Freeman4, Dale P Sandler6. 1. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. 2. Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. 3. Westat Inc., Durham, NC, USA. 4. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 5. Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA. 6. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: sandler@niehs.nih.gov.
Abstract
BACKGROUND: Extensive literature suggests an association between general pesticide use and Parkinson's disease (PD). However, with few exceptions, little is known about associations between specific pesticides and PD. OBJECTIVE: We evaluated use of pesticides and incident PD in 38,274 pesticide applicators and 27,836 of their spouses in the Agricultural Health Study cohort followed over 20 years. METHODS: We used self-reported information on ever-use of 50 specific pesticides as of enrollment for both applicators and spouses, and considered intensity-weighted lifetime days (IWLD) reported at enrollment and through the first 5-year follow-up among applicators. We estimated covariate-adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression. We also examined heterogeneity in associations by history of head injury and chemical resistant glove use. RESULTS: A total of 373 applicators and 118 spouses self-reported incident doctor-diagnosed PD. Ever-use of the insecticide terbufos (HR:1.31, 95%CI:1.02-1.68) and the herbicides trifluralin (HR:1.29, 95%CI: 0.99-1.70) and 2,4,5-T (HR:1.57, 95%CI:1.21-2.04) was associated with elevated PD risk. On the other hand, diazinon (HR:0.73, 95%CI: 0.58-0.94) and 2,4,5-TP (HR:0.39, 95%CI:0.25-0.62) were associated with reduced risk. We observed heterogeneity in ever-use associations by head injury and chemical-resistant glove use for some pesticides, with higher risk among those who reported a history of head injury, or who did not use gloves. PD risk was also elevated for applicators in the highest category of IWLD for dichlorvos, permethrin (animal use), and benomyl. CONCLUSIONS: We found evidence of increased PD risk for some pesticides. Our results also suggest higher susceptibility for pesticide-associated PD among individuals with head injury as well as protection with use of chemical resistant gloves, although further research is needed to understand the impact of head injury. Research on current and newer pesticides, including mechanisms relevant to PD, is important given widespread pesticide use. Published by Elsevier Inc.
BACKGROUND: Extensive literature suggests an association between general pesticide use and Parkinson's disease (PD). However, with few exceptions, little is known about associations between specific pesticides and PD. OBJECTIVE: We evaluated use of pesticides and incident PD in 38,274 pesticide applicators and 27,836 of their spouses in the Agricultural Health Study cohort followed over 20 years. METHODS: We used self-reported information on ever-use of 50 specific pesticides as of enrollment for both applicators and spouses, and considered intensity-weighted lifetime days (IWLD) reported at enrollment and through the first 5-year follow-up among applicators. We estimated covariate-adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression. We also examined heterogeneity in associations by history of head injury and chemical resistant glove use. RESULTS: A total of 373 applicators and 118 spouses self-reported incident doctor-diagnosed PD. Ever-use of the insecticide terbufos (HR:1.31, 95%CI:1.02-1.68) and the herbicides trifluralin (HR:1.29, 95%CI: 0.99-1.70) and 2,4,5-T (HR:1.57, 95%CI:1.21-2.04) was associated with elevated PD risk. On the other hand, diazinon (HR:0.73, 95%CI: 0.58-0.94) and 2,4,5-TP (HR:0.39, 95%CI:0.25-0.62) were associated with reduced risk. We observed heterogeneity in ever-use associations by head injury and chemical-resistant glove use for some pesticides, with higher risk among those who reported a history of head injury, or who did not use gloves. PD risk was also elevated for applicators in the highest category of IWLD for dichlorvos, permethrin (animal use), and benomyl. CONCLUSIONS: We found evidence of increased PD risk for some pesticides. Our results also suggest higher susceptibility for pesticide-associated PD among individuals with head injury as well as protection with use of chemical resistant gloves, although further research is needed to understand the impact of head injury. Research on current and newer pesticides, including mechanisms relevant to PD, is important given widespread pesticide use. Published by Elsevier Inc.
Entities:
Keywords:
Agricultural health study; Farmers; Parkinson's disease; Pesticides
Authors: Che Brown Hutson; Carlos R Lazo; Farzad Mortazavi; Christopher C Giza; David Hovda; Marie-Francoise Chesselet Journal: J Neurotrauma Date: 2011-09 Impact factor: 5.269
Authors: Beate R Ritz; Angelika D Manthripragada; Sadie Costello; Sarah J Lincoln; Matthew J Farrer; Myles Cockburn; Jeff Bronstein Journal: Environ Health Perspect Date: 2009-02-22 Impact factor: 9.031
Authors: Marianne van der Mark; Roel Vermeulen; Peter C G Nijssen; Wim M Mulleners; Antonetta M G Sas; Teus van Laar; Maartje Brouwer; Anke Huss; Hans Kromhout Journal: Occup Environ Med Date: 2014-08-07 Impact factor: 4.402
Authors: Sonya L Heltshe; Jay H Lubin; Stella Koutros; Joseph B Coble; Bu-Tian Ji; Michael C R Alavanja; Aaron Blair; Dale P Sandler; Cynthia J Hines; Kent W Thomas; Joseph Barker; Gabriella Andreotti; Jane A Hoppin; Laura E Beane Freeman Journal: J Expo Sci Environ Epidemiol Date: 2012-05-09 Impact factor: 5.563
Authors: Kent W Thomas; Mustafa Dosemeci; Jane A Hoppin; Linda S Sheldon; Carry W Croghan; Sydney M Gordon; Martin L Jones; Stephen J Reynolds; James H Raymer; Gerald G Akland; Charles F Lynch; Charles E Knott; Dale P Sandler; Aaron E Blair; Michael C Alavanja Journal: J Expo Sci Environ Epidemiol Date: 2009-02-25 Impact factor: 5.563
Authors: Marianne van der Mark; Maartje Brouwer; Hans Kromhout; Peter Nijssen; Anke Huss; Roel Vermeulen Journal: Environ Health Perspect Date: 2012-03 Impact factor: 9.031
Authors: Sandra A Acosta; Naoki Tajiri; Ike de la Pena; Marina Bastawrous; Paul R Sanberg; Yuji Kaneko; Cesar V Borlongan Journal: J Cell Physiol Date: 2015-05 Impact factor: 6.384
Authors: Yaqun Yuan; Srishti Shrestha; Zhehui Luo; Chenxi Li; Brenda L Plassman; Christine G Parks; Jonathan N Hofmann; Laura E Beane Freeman; Dale P Sandler; Honglei Chen Journal: Mov Disord Date: 2022-02-13 Impact factor: 9.698
Authors: Sabrina Tait; Gabriele Lori; Roberta Tassinari; Cinzia La Rocca; Francesca Maranghi Journal: Int J Environ Res Public Health Date: 2022-04-25 Impact factor: 4.614
Authors: Briana R De Miranda; Samuel M Goldman; Gary W Miller; J Timothy Greenamyre; E Ray Dorsey Journal: J Parkinsons Dis Date: 2022 Impact factor: 5.568
Authors: Johan Ohlander; Samuel Fuhrimann; Ioannis Basinas; John W Cherrie; Karen S Galea; Andrew C Povey; Martie van Tongeren; Anne-Helen Harding; Kate Jones; Roel Vermeulen; Anke Huss; Hans Kromhout Journal: Occup Environ Med Date: 2022-04-07 Impact factor: 4.948
Authors: Honglei Chen; Dale P Sandler; Srishti Shrestha; David M Umbach; Laura E Beane Freeman; Stella Koutros; Michael C R Alavanja; Aaron Blair Journal: Occup Environ Med Date: 2020-10-23 Impact factor: 4.402
Authors: Michael Belingheri; Yueh-Hsiu Mathilda Chiu; Stefano Renzetti; Deepika Bhasin; Chi Wen; Donatella Placidi; Manuela Oppini; Loredana Covolo; Alessandro Padovani; Roberto G Lucchini Journal: Int J Environ Res Public Health Date: 2022-03-11 Impact factor: 3.390