Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Proteus mirabilis urease. Partial purification and inhibition by boric acid and boronic acids.

Literature DB >> 3291857

Proteus mirabilis urease. Partial purification and inhibition by boric acid and boronic acids.

Abstract

Urease was purified 800-fold and partially characterized from Proteus mirabilis, the predominant microorganism associated with urinary stones. Boric acid is a rapid reversible competitive inhibitor of urease. The pH-dependence of inhibition exhibited pKa values of 6.25 and 9.3, where the latter value is probably due to the inherent pKa of boric acid. Three boronic acids also were shown to inhibit urease competitively.

Entities: Chemical Species

Mesh：

Substances：

Year: 1988 PMID： 3291857 PMCID： PMC1148943 DOI： 10.1042/bj2500917

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. n-Alkylboronic acids as bifunctional reversible inhibitors of alpha-chymotrypsin.

Authors: V K. Antonov; T V. Ivanina; I V. Berezin; K Martinek
Journal: FEBS Lett Date: 1970-03-16 Impact factor: 4.124

2. X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.

Authors: D A Matthews; R A Alden; J J Birktoft; S T Freer; J Kraut
Journal: J Biol Chem Date: 1975-09-25 Impact factor: 5.157

3. Statistical estimations in enzyme kinetics.

Authors: G N WILKINSON
Journal: Biochem J Date: 1961-08 Impact factor: 3.857

4. Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes.

Authors: L D Sutton; J S Stout; L Hosie; P S Spencer; D M Quinn
Journal: Biochem Biophys Res Commun Date: 1986-01-14 Impact factor: 3.575

5. 2-phenylethaneboronic acid, a possible transition-state analog for chymotrypsin.

Authors: K A Koehler; G E Lienhard
Journal: Biochemistry Date: 1971-06-22 Impact factor: 3.162

6. Urease. The primary cause of infection-induced urinary stones.

Authors: D P Griffith; D M Musher; C Itin
Journal: Invest Urol Date: 1976-03

Review 7. Inhibitors of urease as chemotherapeutic agents.

Authors: I J Rosenstein; J M Hamilton-Miller
Journal: Crit Rev Microbiol Date: 1984 Impact factor: 7.624

Review 8. Urea and urease.

Authors: R K Andrews; R L Blakeley; B Zerner
Journal: Adv Inorg Biochem Date: 1984

7. Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction.

Authors: D L Clemens; B Y Lee; M A Horwitz
Journal: J Bacteriol Date: 1995-10 Impact factor: 3.490

Review 8. Nonredox nickel enzymes.

Authors: Michael J Maroney; Stefano Ciurli
Journal: Chem Rev Date: 2013-12-26 Impact factor: 60.622

9. Cloning and expression of Staphylococcus saprophyticus urease gene sequences in Staphylococcus carnosus and contribution of the enzyme to virulence.

Authors: S Gatermann; R Marre
Journal: Infect Immun Date: 1989-10 Impact factor: 3.441

10. Characterization of urease from Sporosarcina ureae.

Authors: D D McCoy; A Cetin; R P Hausinger
Journal: Arch Microbiol Date: 1992 Impact factor: 2.552

Proteus mirabilis urease. Partial purification and inhibition by boric acid and boronic acids.

1. n-Alkylboronic acids as bifunctional reversible inhibitors of alpha-chymotrypsin.

2. X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.

3. Statistical estimations in enzyme kinetics.

4. Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes.

5. 2-phenylethaneboronic acid, a possible transition-state analog for chymotrypsin.

6. Urease. The primary cause of infection-induced urinary stones.

Review 7. Inhibitors of urease as chemotherapeutic agents.

Review 8. Urea and urease.

9. Expression of functionality of alpha-chymotrypsin. An alternate binding mode in the substrate specificity site.

10. Purification of a nickel-containing urease from the rumen anaerobe Selenomonas ruminantium.

Review 1. Microbial ureases: significance, regulation, and molecular characterization.

Review 2. Potential virulence factors of Proteus bacilli.

Review 3. A review on host-pathogen interactions: classification and prediction.

4. Proteus mirabilis urease: genetic organization, regulation, and expression of structural genes.

5. Ammonium metabolism enzymes aid Helicobacter pylori acid resistance.

Review 6. Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis.

7. Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction.

Review 8. Nonredox nickel enzymes.

9. Cloning and expression of Staphylococcus saprophyticus urease gene sequences in Staphylococcus carnosus and contribution of the enzyme to virulence.

10. Characterization of urease from Sporosarcina ureae.