Literature DB >> 32914973

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

Aled Edwards1.   

Abstract

Massive drug repurposing (or repositioning) campaigns are trying to find potential antiviral treatments for COVID-19. Many involve experimental or virtual screening of libraries of compounds previously proven safe in humans-"old drugs". In 20 years of these efforts in many other diseases, never has a new therapeutic hypothesis derived from screening of old drugs in a lab led to the drug being approved for the new indication.

Entities:  

Year:  2020        PMID： 32914973     DOI： 10.1021/acs.jcim.0c00861

Source DB:  PubMed          Journal:  J Chem Inf Model        ISSN： 1549-9596            Impact factor:   4.956


  18 in total

1.  Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.

Authors:  Henry R O'Donnell; Tia A Tummino; Conner Bardine; Charles S Craik; Brian K Shoichet
Journal:  J Med Chem       Date:  2021-11-23       Impact factor: 7.446

2.  Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach.

Authors:  Heba Abdel-Halim; Malak Hajar; Luma Hasouneh; Suzanne M A Abdelmalek
Journal:  Drug Des Devel Ther       Date:  2022-09-09       Impact factor: 4.319

Review 3.  Phenotypic drug discovery: recent successes, lessons learned and new directions.

Authors:  Fabien Vincent; Arsenio Nueda; Jonathan Lee; Monica Schenone; Marco Prunotto; Mark Mercola
Journal:  Nat Rev Drug Discov       Date:  2022-05-30       Impact factor: 112.288

Review 4.  Nuisance compounds in cellular assays.

Authors:  Jayme L Dahlin; Douglas S Auld; Ina Rothenaigner; Steve Haney; Jonathan Z Sexton; J Willem M Nissink; Jarrod Walsh; Jonathan A Lee; John M Strelow; Francis S Willard; Lori Ferrins; Jonathan B Baell; Michael A Walters; Bruce K Hua; Kamyar Hadian; Bridget K Wagner
Journal:  Cell Chem Biol       Date:  2021-02-15       Impact factor: 8.116

5.  Identification and Development of Therapeutics for COVID-19.

Authors:  Halie M Rando; Nils Wellhausen; Soumita Ghosh; Alexandra J Lee; Anna Ada Dattoli; Fengling Hu; James Brian Byrd; Diane N Rafizadeh; Ronan Lordan; Yanjun Qi; Yuchen Sun; Christian Brueffer; Jeffrey M Field; Marouen Ben Guebila; Nafisa M Jadavji; Ashwin N Skelly; Bharath Ramsundar; Jinhui Wang; Rishi Raj Goel; YoSon Park; Simina M Boca; Anthony Gitter; Casey S Greene
Journal:  mSystems       Date:  2021-11-02       Impact factor: 6.496

Review 6.  Resources and computational strategies to advance small molecule SARS-CoV-2 discovery: lessons from the pandemic and preparing for future health crises.

Authors:  Natesh Singh; Bruno O Villoutreix
Journal:  Comput Struct Biotechnol J       Date:  2021-04-26       Impact factor: 7.271

7.  Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.

Authors:  Tia A Tummino; Veronica V Rezelj; Benoit Fischer; Audrey Fischer; Matthew J O'Meara; Blandine Monel; Thomas Vallet; Ziyang Zhang; Assaf Alon; Henry R O'Donnell; Jiankun Lyu; Heiko Schadt; Kris M White; Nevan J Krogan; Laszlo Urban; Kevan M Shokat; Andrew C Kruse; Adolfo García-Sastre; Olivier Schwartz; Francesca Moretti; Marco Vignuzzi; Francois Pognan; Brian K Shoichet
Journal:  bioRxiv       Date:  2021-03-24

8.  Chemoinformatic Analysis of Psychotropic and Antihistaminic Drugs in the Light of Experimental Anti-SARS-CoV-2 Activities.

Authors:  Bruno O Villoutreix; Rajagopal Krishnamoorthy; Ryad Tamouza; Marion Leboyer; Philippe Beaune
Journal:  Adv Appl Bioinform Chem       Date:  2021-04-12

9.  Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro.

Authors:  Hirofumi Ohashi; Feng Wang; Frank Stappenbeck; Kana Tsuchimoto; Chisa Kobayashi; Wakana Saso; Michiyo Kataoka; Masako Yamasaki; Kouji Kuramochi; Masamichi Muramatsu; Tadaki Suzuki; Camille Sureau; Makoto Takeda; Takaji Wakita; Farhad Parhami; Koichi Watashi
Journal:  Int J Mol Sci       Date:  2021-03-19       Impact factor: 5.923

Review 10.  Advances in the computational landscape for repurposed drugs against COVID-19.

Authors:  Illya Aronskyy; Yosef Masoudi-Sobhanzadeh; Antonio Cappuccio; Elena Zaslavsky
Journal:  Drug Discov Today       Date:  2021-07-30       Impact factor: 7.851
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