R M Graham1, L Jiang1, G McCorkle2, B J Bellando3, S T Sorensen3, C M Glasier1,3, R H Ramakrishnaiah1,3, A C Rowell1, J L Coker4, X Ou5,3,2,6. 1. From the Departments of Radiology (R.M.G., L.J., C.M.G., R.H.R., A.C.R., X.O.). 2. Arkansas Children's Nutrition Center (G.M., X.O.), Little Rock, Arkansas. 3. Pediatrics (B.J.B., S.T.S., C.M.G., R.H.R., X.O.). 4. Psychiatry, and Obstetrics and Gynecology (J.L.C.), University of Arkansas for Medical Sciences, Little Rock, Arkansas. 5. From the Departments of Radiology (R.M.G., L.J., C.M.G., R.H.R., A.C.R., X.O.) ouxiawei@uams.edu. 6. Arkansas Children's Research Institute (X.O.), Little Rock, Arkansas.
Abstract
BACKGROUND AND PURPOSE: Anxiety and depression during pregnancy have been associated with an increased risk of adverse neurodevelopmental outcomes in offspring. We aimed to study the in utero effects of maternal anxiety and depression on early brain development. MATERIALS AND METHODS: Pregnant women were recruited at ∼36 weeks of gestation for this prospective study. They were assessed for anxiety symptoms by the State-Trait Anxiety Inventory and for depression symptoms by the Beck Depression Inventory, 2nd Edition. After delivery, infant underwent an MR imaging examination of the brain without sedation, including DTI, for evaluation of white matter (WM) development. Infant fractional anisotropy values, a putative marker of WM integrity, were correlated with the mothers' State-Trait Anxiety Inventory and Beck Depression Inventory scores by using both tract-based spatial statistics and ROI methods. RESULTS: Thirty-four infants were included in this study. Both maternal State-Anxiety and Trait-Anxiety scores negatively correlated (P < .05, corrected) with fractional anisotropy values in widespread brain WM regions; Beck Depression Inventory scores also negatively correlated (P < .05) with fractional anisotropy values in one cluster in the brain. Further ROI analyses confirmed significant negative correlations between average fractional anisotropy values in ROIs including left and right prefrontal WM, left and right middle frontal gyrus WM, and the fornix, and State-Anxiety (R values, -0.47 to -0.67; P values, .008 to <.001), Trait-Anxiety (R, -0.37 to -0.59; P, .04 to <.001), and Beck Depression Inventory (R values, -0.36 to -0.55; P, .05 to .002) scores. CONCLUSIONS: Higher maternal anxiety and depression symptom scores during late pregnancy were associated with lower estimated infant brain WM development, which indicated in utero influences of maternal mental health during pregnancy on the developing brain.
BACKGROUND AND PURPOSE:Anxiety and depression during pregnancy have been associated with an increased risk of adverse neurodevelopmental outcomes in offspring. We aimed to study the in utero effects of maternal anxiety and depression on early brain development. MATERIALS AND METHODS: Pregnant women were recruited at ∼36 weeks of gestation for this prospective study. They were assessed for anxiety symptoms by the State-Trait Anxiety Inventory and for depression symptoms by the Beck Depression Inventory, 2nd Edition. After delivery, infant underwent an MR imaging examination of the brain without sedation, including DTI, for evaluation of white matter (WM) development. Infant fractional anisotropy values, a putative marker of WM integrity, were correlated with the mothers' State-Trait Anxiety Inventory and Beck Depression Inventory scores by using both tract-based spatial statistics and ROI methods. RESULTS: Thirty-four infants were included in this study. Both maternal State-Anxiety and Trait-Anxiety scores negatively correlated (P < .05, corrected) with fractional anisotropy values in widespread brain WM regions; Beck Depression Inventory scores also negatively correlated (P < .05) with fractional anisotropy values in one cluster in the brain. Further ROI analyses confirmed significant negative correlations between average fractional anisotropy values in ROIs including left and right prefrontal WM, left and right middle frontal gyrus WM, and the fornix, and State-Anxiety (R values, -0.47 to -0.67; P values, .008 to <.001), Trait-Anxiety (R, -0.37 to -0.59; P, .04 to <.001), and Beck Depression Inventory (R values, -0.36 to -0.55; P, .05 to .002) scores. CONCLUSIONS: Higher maternal anxiety and depression symptom scores during late pregnancy were associated with lower estimated infant brain WM development, which indicated in utero influences of maternal mental health during pregnancy on the developing brain.
Authors: Shaili C Jha; Samantha Meltzer-Brody; Rachel J Steiner; Emil Cornea; Sandra Woolson; Mihye Ahn; Audrey R Verde; Robert M Hamer; Hongtu Zhu; Martin Styner; John H Gilmore; Rebecca C Knickmeyer Journal: Psychiatry Res Neuroimaging Date: 2016-05-24 Impact factor: 2.376
Authors: Adomas Bunevicius; Margarita Staniute; Julija Brozaitiene; Victor J M Pop; Julius Neverauskas; Robertas Bunevicius Journal: Health Qual Life Outcomes Date: 2013-03-11 Impact factor: 3.186
Authors: A Qiu; A Rifkin-Graboi; H Chen; Y-S Chong; K Kwek; P D Gluckman; M V Fortier; M J Meaney Journal: Transl Psychiatry Date: 2013-09-24 Impact factor: 6.222
Authors: Rachel E Lean; Christopher D Smyser; Rebecca G Brady; Regina L Triplett; Sydney Kaplan; Jeanette K Kenley; Joshua S Shimony; Tara A Smyser; J Phillip Miller; Deanna M Barch; Joan L Luby; Barbara B Warner; Cynthia E Rogers Journal: Proc Natl Acad Sci U S A Date: 2022-10-11 Impact factor: 12.779
Authors: Catherine H Demers; Maria M Bagonis; Khalid Al-Ali; Sarah E Garcia; Martin A Styner; John H Gilmore; M Camille Hoffman; Benjamin L Hankin; Elysia Poggi Davis Journal: Dev Psychopathol Date: 2021-12-07
Authors: Emily Drzymalla; Nicole Gladish; Nastassja Koen; Michael P Epstein; Michael S Kobor; Heather J Zar; Dan J Stein; Anke Hüls Journal: Transl Psychiatry Date: 2021-11-08 Impact factor: 6.222
Authors: Annerine Roos; Catherine J Wedderburn; Jean-Paul Fouche; Shantanu H Joshi; Katherine L Narr; Roger P Woods; Heather J Zar; Dan J Stein; Kirsten A Donald Journal: Brain Imaging Behav Date: 2022-01-09 Impact factor: 3.224
Authors: Alexandra Lautarescu; Alexandra F Bonthrone; Maximilian Pietsch; Dafnis Batalle; Lucilio Cordero-Grande; J-Donald Tournier; Daan Christiaens; Joseph V Hajnal; Andrew Chew; Shona Falconer; Chiara Nosarti; Suresh Victor; Michael C Craig; A David Edwards; Serena J Counsell Journal: Transl Psychiatry Date: 2022-08-09 Impact factor: 7.989