Cheng-Le Zhuang1, Feng-Min Zhang1, Wei Li2, Kun-Hua Wang3, Hong-Xia Xu4, Chun-Hua Song5, Zeng-Qing Guo6, Han-Ping Shi7. 1. Colorectal Cancer Center, Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China. 2. Cancer Center of the First Hospital of Jilin University, Changchun, China. 3. Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China. 4. Department of Nutrition, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China. 5. Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China. 6. Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China. 7. Departments of Gastrointestinal Surgery and Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Abstract
BACKGROUND: Handgrip strength (HGS) is associated with poor clinical outcomes, including all-cause, non-cardiovascular, and cardiovascular mortalities. The published cut-off points for HGS are mostly based on community populations from Western countries, lacking information on cancer patients from China. The objective of this study was to establish sex-specific cut-off points for Chinese cancer patients and investigate the effect of low HGS on cancer mortality. METHODS: We did a retrospective cohort study of patients who were diagnosed with malignant cancer from June 2012 to December 2018. HGS was measured using a hand dynamometer in 8257 cancer patients. Optimal stratification was used to solve threshold points. The hazard ratio (HR) of all cancer mortality and cancer-specific mortality was calculated using Cox proportional hazard regression models. RESULTS: Among all participants, there were 3902 (47.3%) women and 4355 (52.7%) men. The median age was 58 years old. The cut-off points of HGS to best classify patients with respect to time to mortality were <16.1 kg for women and <22 kg for men. Low HGS was associated with overall cancer mortality in both women and men [HR = 1.339, 95% confidence interval (CI) = 1.170-1.531, P < 0.001; HR = 1.346, 95% CI = 1.176-1.540, P < 0.001, respectively]. For specific cancer types, low HGS was associated with breast cancer (HR = 1.593, 95% CI = 1.230-2.063, P < 0.001) in women, and lung cancer (HR = 1.369, 95% CI = 1.005-1.866, P = 0.047) and colorectal cancer (HR = 1.399, 95% CI = 1.007-1.944, P = 0.045) in men. CONCLUSIONS: On the basis of our sex-specific cut-off points, low HGS was strongly associated with cancer mortalities. These results indicate the usefulness of HGS measurement in routine clinical practice for improving patient assessments, cancer prognosis, and intervention.
BACKGROUND: Handgrip strength (HGS) is associated with poor clinical outcomes, including all-cause, non-cardiovascular, and cardiovascular mortalities. The published cut-off points for HGS are mostly based on community populations from Western countries, lacking information on cancerpatients from China. The objective of this study was to establish sex-specific cut-off points for Chinese cancerpatients and investigate the effect of low HGS on cancer mortality. METHODS: We did a retrospective cohort study of patients who were diagnosed with malignant cancer from June 2012 to December 2018. HGS was measured using a hand dynamometer in 8257 cancerpatients. Optimal stratification was used to solve threshold points. The hazard ratio (HR) of all cancer mortality and cancer-specific mortality was calculated using Cox proportional hazard regression models. RESULTS: Among all participants, there were 3902 (47.3%) women and 4355 (52.7%) men. The median age was 58 years old. The cut-off points of HGS to best classify patients with respect to time to mortality were <16.1 kg for women and <22 kg for men. Low HGS was associated with overall cancer mortality in both women and men [HR = 1.339, 95% confidence interval (CI) = 1.170-1.531, P < 0.001; HR = 1.346, 95% CI = 1.176-1.540, P < 0.001, respectively]. For specific cancer types, low HGS was associated with breast cancer (HR = 1.593, 95% CI = 1.230-2.063, P < 0.001) in women, and lung cancer (HR = 1.369, 95% CI = 1.005-1.866, P = 0.047) and colorectal cancer (HR = 1.399, 95% CI = 1.007-1.944, P = 0.045) in men. CONCLUSIONS: On the basis of our sex-specific cut-off points, low HGS was strongly associated with cancermortalities. These results indicate the usefulness of HGS measurement in routine clinical practice for improving patient assessments, cancer prognosis, and intervention.
Authors: Rubén López-Bueno; Lars Louis Andersen; Joaquín Calatayud; José Casaña; Igor Grabovac; Moritz Oberndorfer; Borja Del Pozo Cruz Journal: Age Ageing Date: 2022-05-01 Impact factor: 12.782
Authors: Rayne de Almeida Marques; Vanusa Felício de Souza; Thainá Cezini do Rosario; Maria Rita Pereira da Silva Garcia; Taísa Sabrina Silva Pereira; José Luiz Marques-Rocha; Valdete Regina Guandalini Journal: PLoS One Date: 2022-07-01 Impact factor: 3.752
Authors: Saulo Gil; Wilson Jacob Filho; Samuel Katsuyuki Shinjo; Eduardo Ferriolli; Alexandre Leopold Busse; Thiago Junqueira Avelino-Silva; Igor Longobardi; Gersiel Nascimento de Oliveira Júnior; Paul Swinton; Bruno Gualano; Hamilton Roschel Journal: J Cachexia Sarcopenia Muscle Date: 2021-09-14 Impact factor: 12.063