Literature DB >> 3290647

p53 increases experimental metastatic capacity of murine carcinoma cells.

J Pohl1, N Goldfinger, A Radler-Pohl, V Rotter, V Schirrmacher.   

Abstract

Transfection of a cloned p53 gene into a murine bladder carcinoma cell with a low metastatic capacity led to elevated levels of p53 protein in clonal transfectants. After intravenous inoculation into syngeneic mice, p53-transfected clones showed significantly increased metastatic potential in comparison with control transfectants. The observed change did not seem to be due to a change in growth potential per se since the cell lines showed similar growth properties in vitro.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3290647      PMCID： PMC363387          DOI： 10.1128/mcb.8.5.2078-2081.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  28 in total

1.  Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

Authors:  S W Kessler
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells.

Authors:  O N Witte; N Rosenberg; M Paskind; A Shields; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

4.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

5.  Inhibition of cell growth mediated by plasmids encoding p53 anti-sense.

Authors:  O Shohat; M Greenberg; D Reisman; M Oren; V Rotter
Journal:  Oncogene       Date:  1987       Impact factor: 9.867

6.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

7.  Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

Authors:  A B DeLeo; G Jay; E Appella; G C Dubois; L W Law; L J Old
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

8.  Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50.

Authors:  V Rotter; O N Witte; R Coffman; D Baltimore
Journal:  J Virol       Date:  1980-11       Impact factor: 5.103

9.  Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens.

Authors:  E G Gurney; R O Harrison; J Fenno
Journal:  J Virol       Date:  1980-06       Impact factor: 5.103

10.  A monoclonal antibody that recognizes B cells and B cell precursors in mice.

Authors:  R L Coffman; I L Weissman
Journal:  J Exp Med       Date:  1981-02-01       Impact factor: 14.307
View more
  16 in total

1.  Induction of the metastatic phenotype by transfection of the nuclear oncogene p53: increases in cytoplasmic diacylglycerol levels and reduction in class I major histocompatibility antigen expression are not sufficient to explain the changes in metastatic capacities.

Authors:  J Pohl; V Lehmann; A Radler-Pohl; V Schirrmacher
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

2.  Comments on 'In vivo selection of human renal carcinoma cells with high metastatic potenital in nude mice'.

Authors:  L Weiss
Journal:  Clin Exp Metastasis       Date:  1990 Jan-Feb       Impact factor: 5.150

3.  Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing.

Authors:  K Will; G Warnecke; L Wiesmüller; W Deppert
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

4.  Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.

Authors:  Yoichi Ohiro; Anny Usheva; Shinichiro Kobayashi; Shannon L Duffy; Regan Nantz; David Gius; Nobuo Horikoshi
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272

Review 5.  A model to account for the effects of oncogenes, TPA, and retinoic acid on the regulation of genes involved in metastasis.

Authors:  J Pohl; A Radler-Pohl; V Schirrmacher
Journal:  Cancer Metastasis Rev       Date:  1988-12       Impact factor: 9.264

6.  An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control.

Authors:  A Gualberto; K Aldape; K Kozakiewicz; T D Tlsty
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

7.  Tumor progression- and metastasis-associated proteins identified using a model of locally recurrent rat mammary adenocarcinomas.

Authors:  D R Welch; S A McClure; P A Aeed; M J Bahner; L D Adams
Journal:  Clin Exp Metastasis       Date:  1990 Nov-Dec       Impact factor: 5.150

Review 8.  Mutant p53 gain-of-function in cancer.

Authors:  Moshe Oren; Varda Rotter
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-02       Impact factor: 10.005

Review 9.  The role of urokinase-type plasminogen activator in aggressive tumor cell behavior.

Authors:  J E Testa; J P Quigley
Journal:  Cancer Metastasis Rev       Date:  1990-12       Impact factor: 9.264

10.  Biomolecular markers in cancer of the tongue.

Authors:  Daris Ferrari; Carla Codecà; Jessica Fiore; Laura Moneghini; Silvano Bosari; Paolo Foa
Journal:  J Oncol       Date:  2009-08-19       Impact factor: 4.375
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.