| Literature DB >> 32901515 |
Anne E Justice1,2, Geetha Chittoor1, Rahul Gondalia2, Phillip E Melton3,4,5, Elise Lim6, Megan L Grove7, Eric A Whitsel2,8, Ching-Ti Liu6, L Adrienne Cupples6,9, Lindsay Fernandez-Rhodes2,10, Weihua Guan11, Jan Bressler7, Myriam Fornage12,13, Eric Boerwinkle7,14, Yun Li15,16, Ellen Demerath17, Nancy Heard-Costa9,18, Dan Levy19,20, James D Stewart2, Andrea Baccarelli21, Lifang Hou22, Karen Conneely23, Trevor A Mori24, Lawrence J Beilin24, Rae-Chi Huang25, Penny Gordon-Larsen26,27, Annie Green Howard15,27, Kari E North2,27.
Abstract
Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP, ADCY7, SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.Entities:
Keywords: DNA methylation; TXNIP; ancestrally diverse; body fat distribution; cardiometabolic disease; central adiposity; methylome-wide association study; waist circumference; waist-to-height ratio; waist-to-hip ratio
Mesh：
Year: 2020 PMID： 32901515 PMCID： PMC7923253 DOI： 10.2217/epi-2019-0276
Source DB: PubMed Journal: Epigenomics ISSN： 1750-192X Impact factor: 4.778