Literature DB >> 3290110

Pathogen specificity of Treponema pallidum subsp. pallidum integral membrane proteins identified by phase partitioning with Triton X-114.

J D Radolf1, M V Norgard.   

Abstract

The antigenically conserved proteins of Treponema pallidum subsp. pallidum and four nonpathogenic cultivatable treponemes were investigated by phase partitioning with the nonionic detergent Triton X-114 and immunoblot analysis. None of the T. pallidum integral membrane proteins identified by phase partitioning (detergent-phase proteins) appeared to be antigenically related to proteins of the nonpathogens. Protease-resistant material similar to lipopolysaccharide was identified in the detergent phase from T. phagedenis biotype Reiter but was not detected in T. pallidum.

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Year:  1988        PMID： 3290110      PMCID： PMC259484          DOI： 10.1128/iai.56.7.1825-1828.1988

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Endotoxemia associated with the Jarisch-Herxheimer reaction.

Authors:  J A Gelfand; R J Elin; F W Berry; M M Frank
Journal:  N Engl J Med       Date:  1976-07-22       Impact factor: 91.245

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.

Authors:  C M Tsai; C E Frasch
Journal:  Anal Biochem       Date:  1982-01-01       Impact factor: 3.365

4.  Phase separation of integral membrane proteins in Triton X-114 solution.

Authors:  C Bordier
Journal:  J Biol Chem       Date:  1981-02-25       Impact factor: 5.157

5.  Monoclonal antibody analysis of specific antigenic similarities among pathogenic Treponema pallidum subspecies.

Authors:  K S Marchitto; S A Jones; R F Schell; P L Holmans; M V Norgard
Journal:  Infect Immun       Date:  1984-09       Impact factor: 3.441

6.  Identification and localization of integral membrane proteins of virulent Treponema pallidum subsp. pallidum by phase partitioning with the nonionic detergent triton X-114.

Authors:  J D Radolf; N R Chamberlain; A Clausell; M V Norgard
Journal:  Infect Immun       Date:  1988-02       Impact factor: 3.441

7.  Genetics of Treponema: relationship between Treponema pallidum and five cultivable treponemes.

Authors:  R Miao; A H Fieldsteel
Journal:  J Bacteriol       Date:  1978-01       Impact factor: 3.490

8.  Identification of Treponema pallidum antigens: comparison with a nonpathogenic treponeme.

Authors:  S A Lukehart; S A Baker-Zander; E R Gubish
Journal:  J Immunol       Date:  1982-08       Impact factor: 5.422

9.  Lack of endotoxin in Borrelia hispanica and Treponema pallidum.

Authors:  P H Hardy; J Levin
Journal:  Proc Soc Exp Biol Med       Date:  1983-10

10.  Studies on the pathogenesis of the Jarisch-Herxheimer reaction: development of an animal model and evidence against a role for classical endotoxin.

Authors:  E J Young; N M Weingarten; R E Baughn; W C Duncan
Journal:  J Infect Dis       Date:  1982-11       Impact factor: 5.226
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  20 in total

1.  The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles.

Authors:  A Centurion-Lara; C Godornes; C Castro; W C Van Voorhis; S A Lukehart
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

Review 2.  Biological basis for syphilis.

Authors:  Rebecca E Lafond; Sheila A Lukehart
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

3.  Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins.

Authors:  M E Brandt; B S Riley; J D Radolf; M V Norgard
Journal:  Infect Immun       Date:  1990-04       Impact factor: 3.441

4.  Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).

Authors:  Chad A Brautigam; Ranjit K Deka; Peter Schuck; Diana R Tomchick; Michael V Norgard
Journal:  J Mol Biol       Date:  2012-04-11       Impact factor: 5.469

5.  Cloning and DNA sequence analysis of an immunogenic glucose-galactose MglB lipoprotein homologue from Brachyspira pilosicoli, the agent of colonic spirochetosis.

Authors:  P Zhang; X Cheng; G E Duhamel
Journal:  Infect Immun       Date:  2000-08       Impact factor: 3.441

6.  The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum.

Authors:  D L Cox; P Chang; A W McDowall; J D Radolf
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

7.  Major integral membrane protein immunogens of Treponema pallidum are proteolipids.

Authors:  N R Chamberlain; M E Brandt; A L Erwin; J D Radolf; M V Norgard
Journal:  Infect Immun       Date:  1989-09       Impact factor: 3.441

8.  Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity.

Authors:  D R Akins; B K Purcell; M M Mitra; M V Norgard; J D Radolf
Journal:  Infect Immun       Date:  1993-04       Impact factor: 3.441

9.  Purification and immunological characterization of a major low-molecular-weight lipoprotein from Borrelia burgdorferi.

Authors:  L I Katona; G Beck; G S Habicht
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

10.  Antigenic composition of Borrelia burgdorferi during infection of SCID mice.

Authors:  Timothy R Crother; Cheryl I Champion; Xiao-Yang Wu; David R Blanco; James N Miller; Michael A Lovett
Journal:  Infect Immun       Date:  2003-06       Impact factor: 3.441
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