Zahra Heidari1, Bita Moudi1, Hamidreza Mahmoudzadeh-Sagheb1. 1. Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Histology, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract
BACKGROUND AND AIMS: Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-γ and IFN-γR1 genes may influence the susceptibility to HBV. Here, we evaluated the impact of interferon gamma (+874 T/A) and its receptor (-611A/G, +189G/C and +95C/T) polymorphisms and the risk of HBV in Iranian patients. MATERIALS AND METHODS: SNPs of interferon gamma and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using ARMS-PCR and PCR- RFLP method. RESULTS: In this study, we showed an obvious relationship between IFN-γ SNPs and susceptibility to chronic HBV. Our findings suggest that IFN-γ-874A allele increases the risk of disease and carriers of the T allele have reduced susceptibility to infection. In addition, there was not any relationship between the -611A/G, +189G/C and +95C/T regions of IFN-γ R1 and HBV. CONCLUSIONS: Our observations demonstrate +874 T/A SNP as a predicting factor in patients who have the risk of HBV.
BACKGROUND AND AIMS: Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-γ and IFN-γR1 genes may influence the susceptibility to HBV. Here, we evaluated the impact of interferon gamma (+874 T/A) and its receptor (-611A/G, +189G/C and +95C/T) polymorphisms and the risk of HBV in Iranian patients. MATERIALS AND METHODS: SNPs of interferon gamma and its receptor genotypes were determined in 221 infectedpatients with HBV and 200 people without HBV using ARMS-PCR and PCR- RFLP method. RESULTS: In this study, we showed an obvious relationship between IFN-γ SNPs and susceptibility to chronic HBV. Our findings suggest that IFN-γ-874A allele increases the risk of disease and carriers of the T allele have reduced susceptibility to infection. In addition, there was not any relationship between the -611A/G, +189G/C and +95C/T regions of IFN-γ R1 and HBV. CONCLUSIONS: Our observations demonstrate +874 T/A SNP as a predicting factor in patients who have the risk of HBV.
Authors: Simone R S Conde; Rosimar N M Feitosa; Felipe Bonfim Freitas; Renata B Hermes; Samia Demachki; Marialva T F Araújo; Manoel C P Soares; Ricardo Ishak; Antonio C R Vallinoto Journal: Cytokine Date: 2013-02-08 Impact factor: 3.861
Authors: Jae Youn Cheong; Sung Won Cho; Il Lan Hwang; Seung Kew Yoon; June Hyuk Lee; Choon Sik Park; Jong Eun Lee; Ki Baik Hahm; Jin Hong Kim Journal: J Gastroenterol Hepatol Date: 2006-07 Impact factor: 4.029
Authors: Simone Jüliger; Martina Bongartz; Adrian J F Luty; Peter G Kremsner; Jürgen F J Kun Journal: Immunogenetics Date: 2002-12-14 Impact factor: 2.846
Authors: L Bulat-Kardum; G E Etokebe; J Knezevic; S Balen; N Matakovic-Mileusnic; L Zaputovic; J Pavelic; Z Beg-Zec; Z Dembic Journal: Scand J Immunol Date: 2006-02 Impact factor: 3.487