| Literature DB >> 32895522 |
Wilson Poon1,2, Benjamin R Kingston1,2, Ben Ouyang1,2,3, Wayne Ngo1,2, Warren C W Chan4,5,6,7,8.
Abstract
The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials are promising vehicles to transport agents that include drugs, contrast agents, immunotherapies and gene editors. They can be engineered to have different physical and chemical properties that influence their interactions with their biological environments and delivery destinations. In this Review Article, we discuss nanoparticle delivery systems and how the biology of disease should inform their design. We propose developing a framework for building optimal delivery systems that uses nanoparticle-biological interaction data and computational analyses to guide future nanomaterial designs and delivery strategies.Entities:
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Year: 2020 PMID： 32895522 DOI： 10.1038/s41565-020-0759-5
Source DB: PubMed Journal: Nat Nanotechnol ISSN： 1748-3387 Impact factor: 39.213