Kazuki Ishikawa1, Tsuneo Yamashiro1, Takuro Ariga2,3, Takafumi Toita1,4, Wataru Kudaka5, Joichi Heianna1, Hitoshi Maemoto1, Takeaki Kusada1, Wataru Makino1, Yoichi Aoki5, Sadayuki Murayama1. 1. Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. 2. Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. arigatak@med.u-ryukyu.ac.jp. 3. Health Information Management Center, University of the Ryukyus Hospital, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. arigatak@med.u-ryukyu.ac.jp. 4. Radiation Therapy Center, Okinawa Chubu Hospital, 281 Miyazato, Uruma, Okinawa, 904-2293, Japan. 5. Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
Abstract
PURPOSE: Fractures are known to shorten life expectancy and worsen the quality of life. The risk of fractures after radiation therapy in cervical cancer patients is known to be multifactorial. In this study, we examined risk factors for fractures in cervical cancer patients, especially by evaluating bone densities and DVH parameters for fractured bones. MATERIALS AND METHODS: For 42 patients, clinical characteristics, pretreatment CT bone densities, and radiation dose were compared between patients with and without fractures. RESULTS: Posttreatment fractures occurred in 25 bones among ten patients. Pretreatment CT bone densities were significantly lower in patients with fractures (P < 0.05-0.01 across sites, except for the ilium and the ischium). Although DVH parameters were also significantly associated with fractures in univariate analysis, only CT densities were significantly associated with fractures in multivariate analysis. CONCLUSION: Pretreatment CT densities of spinal and pelvic bones, which may reflect osteoporosis, have a significant impact on the risk for posttreatment fractures.
PURPOSE:Fractures are known to shorten life expectancy and worsen the quality of life. The risk of fractures after radiation therapy in cervical cancerpatients is known to be multifactorial. In this study, we examined risk factors for fractures in cervical cancerpatients, especially by evaluating bone densities and DVH parameters for fractured bones. MATERIALS AND METHODS: For 42 patients, clinical characteristics, pretreatment CT bone densities, and radiation dose were compared between patients with and without fractures. RESULTS: Posttreatment fractures occurred in 25 bones among ten patients. Pretreatment CT bone densities were significantly lower in patients with fractures (P < 0.05-0.01 across sites, except for the ilium and the ischium). Although DVH parameters were also significantly associated with fractures in univariate analysis, only CT densities were significantly associated with fractures in multivariate analysis. CONCLUSION: Pretreatment CT densities of spinal and pelvic bones, which may reflect osteoporosis, have a significant impact on the risk for posttreatment fractures.
Authors: Anne Ramlov; Erik Morre Pedersen; Lisbeth Røhl; Esben Worm; Lars Fokdal; Jacob Chr Lindegaard; Kari Tanderup Journal: Int J Radiat Oncol Biol Phys Date: 2017-03-15 Impact factor: 7.038
Authors: Kathleen M Schmeler; Anuja Jhingran; Revathy B Iyer; Charlotte C Sun; Patricia J Eifel; Pamela T Soliman; Pedro T Ramirez; Michael Frumovitz; Diane C Bodurka; Anil K Sood Journal: Cancer Date: 2010-02-01 Impact factor: 6.860
Authors: Dongryul Oh; Seung Jae Huh; Heerim Nam; Won Park; Youngyih Han; Do Hoon Lim; Yong Chan Ahn; Jeong Won Lee; Byoung Gie Kim; Duk Soo Bae; Je Ho Lee Journal: Int J Radiat Oncol Biol Phys Date: 2007-10-24 Impact factor: 7.038
Authors: George Ioannidis; Alexandra Papaioannou; Wilma M Hopman; Noori Akhtar-Danesh; Tassos Anastassiades; Laura Pickard; Courtney C Kennedy; Jerilynn C Prior; Wojciech P Olszynski; Kenneth S Davison; David Goltzman; Lehana Thabane; Amiran Gafni; Emmanuel A Papadimitropoulos; Jacques P Brown; Robert G Josse; David A Hanley; Jonathan D Adachi Journal: CMAJ Date: 2009-08-04 Impact factor: 8.262