Pyry N Sipilä1,2, Joni V Lindbohm1,3, Archana Singh-Manoux3,4, Martin J Shipley3, Tuomo Kiiskinen5, Aki S Havulinna5,6, Jussi Vahtera7,8, Solja T Nyberg1,9, Jaana Pentti1,7,9, Mika Kivimäki1,2,3. 1. Clinicum, Department of Public Health, University of Helsinki, Helsinki, Finland. 2. Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland. 3. Department of Epidemiology and Public Health, University College London, London, UK. 4. INSERM U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, Paris, France. 5. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. 6. National Institute for Health and Welfare, Helsinki, Finland. 7. Department of Public Health, University of Turku, Turku, Finland. 8. Turku University Hospital, Turku, Finland. 9. Finnish Institute of Occupational Health, Helsinki, Finland.
Abstract
INTRODUCTION: Conventional risk factors targeted by prevention (e.g., low education, smoking, and obesity) are associated with a 1.2- to 2-fold increased risk of dementia. It is unclear whether having a physical disease is an equally important risk factor for dementia. METHODS: In this exploratory multicohort study of 283,414 community-dwelling participants, we examined 22 common hospital-treated physical diseases as risk factors for dementia. RESULTS: During a median follow-up of 19 years, a total of 3416 participants developed dementia. Those who had erysipelas (hazard ratio = 1.82; 95% confidence interval = 1.53 to 2.17), hypothyroidism (1.94; 1.59 to 2.38), myocardial infarction (1.41; 1.20 to 1.64), ischemic heart disease (1.32; 1.18 to 1.49), cerebral infarction (2.44; 2.14 to 2.77), duodenal ulcers (1.88; 1.42 to 2.49), gastritis and duodenitis (1.82; 1.46 to 2.27), or osteoporosis (2.38; 1.75 to 3.23) were at a significantly increased risk of dementia. These associations were not explained by conventional risk factors or reverse causation. DISCUSSION: In addition to conventional risk factors, several physical diseases may increase the long-term risk of dementia.
INTRODUCTION: Conventional risk factors targeted by prevention (e.g., low education, smoking, and obesity) are associated with a 1.2- to 2-fold increased risk of dementia. It is unclear whether having a physical disease is an equally important risk factor for dementia. METHODS: In this exploratory multicohort study of 283,414 community-dwelling participants, we examined 22 common hospital-treated physical diseases as risk factors for dementia. RESULTS: During a median follow-up of 19 years, a total of 3416 participants developed dementia. Those who had erysipelas (hazard ratio = 1.82; 95% confidence interval = 1.53 to 2.17), hypothyroidism (1.94; 1.59 to 2.38), myocardial infarction (1.41; 1.20 to 1.64), ischemic heart disease (1.32; 1.18 to 1.49), cerebral infarction (2.44; 2.14 to 2.77), duodenal ulcers (1.88; 1.42 to 2.49), gastritis and duodenitis (1.82; 1.46 to 2.27), or osteoporosis (2.38; 1.75 to 3.23) were at a significantly increased risk of dementia. These associations were not explained by conventional risk factors or reverse causation. DISCUSSION: In addition to conventional risk factors, several physical diseases may increase the long-term risk of dementia.
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Authors: Pyry N Sipilä; Joni V Lindbohm; Archana Singh-Manoux; Martin J Shipley; Tuomo Kiiskinen; Aki S Havulinna; Jussi Vahtera; Solja T Nyberg; Jaana Pentti; Mika Kivimäki Journal: Alzheimers Dement Date: 2020-09-04 Impact factor: 16.655
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