Javier Orduña-Azcona1,2, Elia Pérez-Fernández3, Ana M Guadilla4, Sofía De Manuel-Triantafilo5, Laura Modamio5,4, Pablo Gili5. 1. Ophthalmology Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain. dr.orduna@outlook.com. 2. Ophthalmology Unit, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain. dr.orduna@outlook.com. 3. Research Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain. 4. Ophthalmology Unit, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain. 5. Ophthalmology Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain.
Abstract
PURPOSE: To evaluate the utility of choroidal thickness (CT) measurement by enhanced depth imaging optical coherence tomography (EDI-OCT) for central serous chorioretinopathy (CSC) diagnosis. METHODS: Cross-sectional comparative study of 62 consecutive patients: 38 with acute CSC and 24 with macular subretinal fluid from differential diagnoses (DD). Subfoveolar choroidal thickness was measured using EDI 9-mm horizontal protocol. We evaluated sensitivity, specificity and intraclass correlation coefficient. RESULTS: Mean subfoveolar CT was greater in CSC group than in DD group (465.45 ± 115.42 μm vs. 347.54 ± 111.27 μm, p < 0.001). The best threshold measure was 390 μm in patients younger than 50 years giving a sensitivity of 89.7% (CI 95%: 73.6-100%) and a specificity of 75% (CI 95%: 40.9-87.3%). For patients older than 50 years best threshold measure was found at 400 μm giving a sensitivity of 45.5% (CI 95%: 21.3-72%) and a specificity of 80% (CI 95%: 58.4-91.9%). Intraclass correlation coefficient for CT measurement was 0.87 (CI 95%: 0.74-0.93). CONCLUSION: CT measurement with EDI-OCT helps to differentiate CSC from other causes of macular subretinal fluid in patients younger than 50 years.
PURPOSE: To evaluate the utility of choroidal thickness (CT) measurement by enhanced depth imaging optical coherence tomography (EDI-OCT) for central serous chorioretinopathy (CSC) diagnosis. METHODS: Cross-sectional comparative study of 62 consecutive patients: 38 with acute CSC and 24 with macular subretinal fluid from differential diagnoses (DD). Subfoveolar choroidal thickness was measured using EDI 9-mm horizontal protocol. We evaluated sensitivity, specificity and intraclass correlation coefficient. RESULTS: Mean subfoveolar CT was greater in CSC group than in DD group (465.45 ± 115.42 μm vs. 347.54 ± 111.27 μm, p < 0.001). The best threshold measure was 390 μm in patients younger than 50 years giving a sensitivity of 89.7% (CI 95%: 73.6-100%) and a specificity of 75% (CI 95%: 40.9-87.3%). For patients older than 50 years best threshold measure was found at 400 μm giving a sensitivity of 45.5% (CI 95%: 21.3-72%) and a specificity of 80% (CI 95%: 58.4-91.9%). Intraclass correlation coefficient for CT measurement was 0.87 (CI 95%: 0.74-0.93). CONCLUSION: CT measurement with EDI-OCT helps to differentiate CSC from other causes of macular subretinal fluid in patients younger than 50 years.
Entities:
Keywords:
Central serous chorioretinopathy; Choroidal thickness; Optical coherence tomography; ROC curve; Sensitivity and specificity
Authors: Jamin S Brown; D Ian Flitcroft; Gui-shuang Ying; Ellie L Francis; Gregor F Schmid; Graham E Quinn; Richard A Stone Journal: Invest Ophthalmol Vis Sci Date: 2008-08-21 Impact factor: 4.799