Roberto Onner Cruz Tapia1, Alberto Jose Peraza Labrador2, Douglas Magno Guimaraes3, Luciano Hermios Matos Valdez4. 1. Department of Oral and Maxillofacial Pathology, Postgraduate and Research Division, Universidad Nacional Autónoma de México, Mexico City, Mexico. 2. Department of Oral and Maxillofacial Pathology, Universidad El Bosque, Bogota, Colombia. 3. School of Dentistry, Centro Universitario do Estado do Para, Belem, Brazil. 4. Faculty of Dentistry, Postgraduate Unit, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Abstract
BACKGROUND: Vesiculobullous and macular lesions in the oral mucosa have been reported in patients positive for SARS-CoV-2 infection. Nonetheless, the significance and physiopathology of oral manifestations have not been clearly established in the clinical progression or outcome of the infection. AIM: To describe the clinico-pathological oral mucosal lesions in four patients with confirmed SARS-CoV-2 infection. METHODS AND RESULTS: Four patients with COVID-19 disease and confirmed by polymerase chain reaction (PCR) presented angina bullosa hemorragica-like lesion, vascular disorder, and nonspecific stomatitis, one patient with histological analysis demonstrated perivascular reactive lymphocitic infliltrate, focal capillary thrombosis, and hemorrhage. According to the discrimination of other local and systemic conditions and the synchronous onset of oral and systemic symptoms, the diagnosis of oral lesions probably associated with COVID-19 was established. CONCLUSION: Infection with SARS-CoV-2 may result in oral manifestations with various clinical presentations, which presumably support the hypothesis of thrombi formation and vasculitis; nevertheless, these findings need more evidence and a long-term follow up of patients to accurately establish the significance of the oral mucosa affection in the COVID-19 disease.
BACKGROUND: Vesiculobullous and macular lesions in the oral mucosa have been reported in patients positive for SARS-CoV-2 infection. Nonetheless, the significance and physiopathology of oral manifestations have not been clearly established in the clinical progression or outcome of the infection. AIM: To describe the clinico-pathological oral mucosal lesions in four patients with confirmed SARS-CoV-2 infection. METHODS AND RESULTS: Four patients with COVID-19 disease and confirmed by polymerase chain reaction (PCR) presented angina bullosa hemorragica-like lesion, vascular disorder, and nonspecific stomatitis, one patient with histological analysis demonstrated perivascular reactive lymphocitic infliltrate, focal capillary thrombosis, and hemorrhage. According to the discrimination of other local and systemic conditions and the synchronous onset of oral and systemic symptoms, the diagnosis of oral lesions probably associated with COVID-19 was established. CONCLUSION: Infection with SARS-CoV-2 may result in oral manifestations with various clinical presentations, which presumably support the hypothesis of thrombi formation and vasculitis; nevertheless, these findings need more evidence and a long-term follow up of patients to accurately establish the significance of the oral mucosa affection in the COVID-19 disease.
Authors: A Nuño González; K Magaletskyy; P Martín Carrillo; B Lozano Masdemont; A Mayor Ibarguren; M Feito Rodríguez; P Herranz Pinto Journal: Actas Dermosifiliogr (Engl Ed) Date: 2021-05-12
Authors: Grecia Riofrio; Stephanny Castillo; Gabriela Salcedo; Daniel Alvitez-Temoche; Romel Watanabe; Frank Mayta-Tovalino Journal: J Int Soc Prev Community Dent Date: 2021-06-10