Lisa A Brenner1, Christopher E Stamper, Andrew J Hoisington, Kelly A Stearns-Yoder, Maggie A Stanislawksi, Diana P Brostow, Claire A Hoffmire, Jeri E Forster, Alexandra L Schneider, Teodor T Postolache, Christopher A Lowry. 1. Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional VA Medical Center, Aurora, Colorado (Drs Brenner, Stamper, Hoisington, Stearns-Yoder, Stanislawksi, Brostow, Hoffmire, Forster, Schneider, Postolache, and Lowry); Department of Physical Medicine and Rehabilitation (Drs Brenner, Stamper, Hoisington, Stearns-Yoder, Brostow, Hoffmire, Forster, and Lowry), Departments of Psychiatry and Neurology (Dr Brenner), Division of Biomedical Informatics and Personalized Medicine (Dr Stanislawksi), and Center for Neuroscience (Dr Lowry), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Military and Veteran Microbiome: Consortium for Research and Education, Aurora, Colorado (Drs Brenner, Stamper, Hoisington, Stearns-Yoder, Brostow, Hoffmire, Forster, Schneider, Postolache, and Lowry); Department of Systems Engineering and Management, Air Force Institute of Technology, Wright-Patterson AFB, Ohio (Dr Hoisington); Mood and Anxiety Program, University of Maryland School of Medicine, and VISN 5 MIRECC, Department of Veterans Affairs, Baltimore, Maryland (Dr Postolache); and Department of Integrative Physiology, and Center for Neuroscience, University of Colorado Boulder, Boulder (Dr Lowry).
Abstract
OBJECTIVE: To evaluate the association between distal moderate/severe traumatic brain injury (TBI) history and the human gut microbiome. SETTING: Veterans Affairs Medical Center. PARTICIPANTS: Veterans from the United States-Veteran Microbiome Project (US-VMP). Veterans with moderate/severe TBI (n = 34) were compared with (1) Veterans with a history of no TBI (n = 79) and (2) Veterans with a history of no TBI or mild TBI only (n = 297). DESIGN: Microbiome analyses from 16S rRNA gene sequencing with gut microbiota function inferred using PICRUSt2. MAIN MEASURES: α-Diversity and β-diversity of the gut microbiome, as well as taxonomic and functional signatures associated with moderate/severe TBI. RESULTS: There were no significant differences in gut bacterial α- and β-diversity associated with moderate/severe TBI status. No differentially abundant taxa were identified when comparing samples from moderate/severe TBI to those with no TBI or no TBI/mild TBI. CONCLUSION: Results suggest that moderate/severe TBI-related changes to the gut microbiome do not persist for years postinjury.
OBJECTIVE: To evaluate the association between distal moderate/severe traumatic brain injury (TBI) history and the humangut microbiome. SETTING: Veterans Affairs Medical Center. PARTICIPANTS: Veterans from the United States-Veteran Microbiome Project (US-VMP). Veterans with moderate/severe TBI (n = 34) were compared with (1) Veterans with a history of no TBI (n = 79) and (2) Veterans with a history of no TBI or mild TBI only (n = 297). DESIGN: Microbiome analyses from 16S rRNA gene sequencing with gut microbiota function inferred using PICRUSt2. MAIN MEASURES: α-Diversity and β-diversity of the gut microbiome, as well as taxonomic and functional signatures associated with moderate/severe TBI. RESULTS: There were no significant differences in gut bacterial α- and β-diversity associated with moderate/severe TBI status. No differentially abundant taxa were identified when comparing samples from moderate/severe TBI to those with no TBI or no TBI/mild TBI. CONCLUSION: Results suggest that moderate/severe TBI-related changes to the gut microbiome do not persist for years postinjury.