| Literature DB >> 32879300 |
Yangli Xie1, Nan Su2, Jing Yang2, Qiaoyan Tan2, Shuo Huang2, Min Jin2, Zhenhong Ni2, Bin Zhang2, Dali Zhang2, Fengtao Luo2, Hangang Chen2, Xianding Sun2, Jian Q Feng3, Huabing Qi4, Lin Chen5.
Abstract
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.Entities:
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Year: 2020 PMID： 32879300 PMCID： PMC7468161 DOI： 10.1038/s41392-020-00222-7
Source DB: PubMed Journal: Signal Transduct Target Ther ISSN： 2059-3635