| Literature DB >> 32876860 |
Ying-Xin Sun1, Xi-Juan Jiang1, Bin Lu1, Qing Gao1, Ye-Fei Chen1, Dan-Bin Wu1, Wen-Yun Zeng1, Lin Yang1, Hu-Hu Li1, Bin Yu2.
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD. Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed. The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.Entities:
Keywords: Alzheimer’s disease; Chinese medicine; gut microbiota; pathogenesis
Year: 2020 PMID： 32876860 DOI： 10.1007/s11655-020-3274-5
Source DB: PubMed Journal: Chin J Integr Med ISSN： 1672-0415 Impact factor: 2.626