Ahmad M Mansour1,2, Ayman G Elnahry3, Koushik Tripathy4,5, Robert E Foster6, Carl-Jo Mehanna7, Raval Vishal8, Cemal Çavdarlı9, Alessandro Arrigo10,11, Maurizio Battaglia Parodi12. 1. Department of Ophthalmology, American University of Beirut, Beirut, Lebanon. ammansourmd@gmail.com. 2. Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon. ammansourmd@gmail.com. 3. Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt. 4. Department of Ophthalmology, Department of Retina and Uvea, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. 5. Department of Vitreoretina and Uvea, ASG Eye Hospital, 149 BT Road, Near Kamarhati More, Kolkata, India. 6. Department of Ophthalmology, University of Cincinnati, CIncinnati Eye Institute, Cincinnati, OH, USA. 7. Department of Ophthalmology, American University of Beirut, Beirut, Lebanon. 8. L.V. Prasad Eye Institute, Kode Venkatadri Chowdary Campus, Tadigadapa, India. 9. Department of Ophthalmology, Ankara City Hospital, MHC Blok Bilent University, Ankara, Turkey. 10. Department of Ophthalmology Ospedale San Raffaele, University Vita-Salute Milan, Milano, Italy. 11. Department of Biomedical sciences and morphological and functional imaging, University of Messina, Messina, Italy. 12. Department of Ophthalmology Ospedale San Raffaele, University Vita-Salute Milan, Milano, Italy. maubp@yahoo.it.
Abstract
BACKGROUND: To evaluate the relationship between superficial, deep foveal avascular zone (FAZ) and foveal cyst areas in eyes with cystoid macular oedema (CMO) associated with gyrate atrophy of the choroid and retina (GA). METHODS: This is a retrospective collaborative multicenter study of optical coherence tomography-angiography (OCTA) images in GA. Superficial and deep FAZ and foveal cyst were measured using Image J by two independent experts. Values were corrected for myopia magnification. These values were compared with age-matched controls from normative data. RESULTS: Twenty-three eyes from 12 patients with GA and CMO were included in the study. The mean ± standard deviation age was 22 ± 19.7 years, mean Snellen spectacle-corrected visual acuity of 20/70 with mean myopia of 5.7 ± 4.1 dioptres. Qualitatively, no focal occlusion of superficial and deep capillary plexus was noted. Mean superficial FAZ area (0.484 ± 0.317 mm2), deep FAZ area (0.626 ± 0.452 mm2), and foveal cyst area (0.630 ± 0.503 mm2) were significantly larger than superficial and deep FAZ areas in controls of same age range (p < 0.001). Macular cyst area correlated with superficial FAZ area (R = 0.59; p = 0.0057) and more strongly with deep FAZ area (R = 0.69; p < 0.001). CONCLUSIONS: The superficial and deep FAZ area in GA-associated CMO were noted to be significantly larger than in controls. It seems that RPE dysfunction leads to foveal cyst enlargement displacing the capillary plexus with resultant enlarged superficial and deep FAZ area.
BACKGROUND: To evaluate the relationship between superficial, deep foveal avascular zone (FAZ) and foveal cyst areas in eyes with cystoid macular oedema (CMO) associated with gyrate atrophy of the choroid and retina (GA). METHODS: This is a retrospective collaborative multicenter study of optical coherence tomography-angiography (OCTA) images in GA. Superficial and deep FAZ and foveal cyst were measured using Image J by two independent experts. Values were corrected for myopia magnification. These values were compared with age-matched controls from normative data. RESULTS: Twenty-three eyes from 12 patients with GA and CMO were included in the study. The mean ± standard deviation age was 22 ± 19.7 years, mean Snellen spectacle-corrected visual acuity of 20/70 with mean myopia of 5.7 ± 4.1 dioptres. Qualitatively, no focal occlusion of superficial and deep capillary plexus was noted. Mean superficial FAZ area (0.484 ± 0.317 mm2), deep FAZ area (0.626 ± 0.452 mm2), and foveal cyst area (0.630 ± 0.503 mm2) were significantly larger than superficial and deep FAZ areas in controls of same age range (p < 0.001). Macular cyst area correlated with superficial FAZ area (R = 0.59; p = 0.0057) and more strongly with deep FAZ area (R = 0.69; p < 0.001). CONCLUSIONS: The superficial and deep FAZ area in GA-associated CMO were noted to be significantly larger than in controls. It seems that RPE dysfunction leads to foveal cyst enlargement displacing the capillary plexus with resultant enlarged superficial and deep FAZ area.