Tiffany Darbas1, Geraud Forestier2, Sophie Leobon1, Julia Pestre1, Pierre Jesus3, Denis Lachatre2, Nicole Tubiana-Mathieu1, Aurelien Descazeaud4, Elise Deluche5. 1. Department of Medical Oncology, Limoges University Hospital, Limoges, France. 2. Department of Radiology, Limoges University Hospital, Limoges, France. 3. Nutrition Unit, Limoges University Hospital, Limoges, France. 4. Department of Urology, Limoges University Hospital, Limoges, France. 5. Department of Medical Oncology, Limoges University Hospital, Limoges, France elise.deluche@chu-limoges.fr.
Abstract
BACKGROUND/AIM: To investigate the impact of body composition on morbidity and mortality at the initial diagnosis of localised renal cell carcinoma (RCC) in patients with overweight or obesity. PATIENTS AND METHODS: Sarcopenia was defined using sex-specific cut-off points and other body composition parameters by median values with computed tomography imaging. RESULTS: Among the 96 patients, 40 had sarcopenia (43.0%) at diagnosis. Body composition had no effect on morbidity and 5-year disease-free survival contrary to the classic factors (p<0.05). In the subgroup of obese patients, those with sarcopenia had a poor prognosis (p=0.04) but not in the population with overweight (p=0.9). CONCLUSION: Sarcopenia was frequently associated with localised RCC at the initial diagnosis. Body composition did not affect morbidity or outcomes. BMI was involved in morbidity and there was paradoxically longer survival in the obesity group. Copyright
BACKGROUND/AIM: To investigate the impact of body composition on morbidity and mortality at the initial diagnosis of localised renal cell carcinoma (RCC) in patients with overweight or obesity. PATIENTS AND METHODS: Sarcopenia was defined using sex-specific cut-off points and other body composition parameters by median values with computed tomography imaging. RESULTS: Among the 96 patients, 40 had sarcopenia (43.0%) at diagnosis. Body composition had no effect on morbidity and 5-year disease-free survival contrary to the classic factors (p<0.05). In the subgroup of obesepatients, those with sarcopenia had a poor prognosis (p=0.04) but not in the population with overweight (p=0.9). CONCLUSION:Sarcopenia was frequently associated with localised RCC at the initial diagnosis. Body composition did not affect morbidity or outcomes. BMI was involved in morbidity and there was paradoxically longer survival in the obesity group. Copyright
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