Hanna Tuominen1, Mikko Taina2,3, Mirja Puranen4,5, Juha Onatsu6, Sisko Huumonen7,3, Ritva Vanninen2,3. 1. The Institute of Dentistry, University of Eastern Finland, Kuopio, Finland hannatai@student.uef.fi. 2. Unit of Radiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. 3. Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland. 4. Department of Pathology, Kuopio University Hospital, Kuopio, Finland. 5. Oral and Maxillofacial Department, Kuopio University Hospital, Kuopio, Finland. 6. NeuroCenter, Kuopio University Hospital, Kuopio, Finland. 7. The Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Abstract
BACKGROUND/AIM: Chronic infectious diseases are believed to increase the risk of stroke. We aimed to evaluate the prevalence of periodontal disease and its association with systemic inflammatory processes in patients suffering an acute stroke/transient ischemic attack (TIA). PATIENTS AND METHODS: Altogether 36 acute stroke/TIA patients underwent clinical, laboratory and radiological examinations. The level of systemic inflammation was analyzed both with routine measurements of plasma C-reactive protein (p-CRP) and serum high-sensitivity CRP (s-hsCRP) to analyze their associations with periodontitis. The diagnostic criteria for periodontitis included increased probing depth (>4 mm) measured from four different sites, bleeding on probing, and horizontal (>1 mm), vertical (>1 mm) or apical bone loss observed on orthopantomography. RESULTS: Twenty-six (72.2%) patients were diagnosed with periodontitis. Only five of the patients with periodontitis (19.2%) had elevated p-CRP values whereas the majority, (17/26; 65.4%) had elevated s-hsCRP values (p<0.01). Absolute s-hsCRP values in patients with periodontitis (8.9±12.5 mg/l) were significantly higher than in patients without periodontitis (2.3±3.0 mg/l; p<0.05). Absolute p-CRP concentrations did not differ (2.3±5.8 vs. 2.4±5.1 mg/l; p=not significant). The total number of periodontitis findings was significantly associated with s-hsCRP values (r=1.83) but not with p-CRP values. Conversely, seventeen of the nineteen patients with elevated s-hsCRP (89.5%) indicative of systemic inflammation had periodontitis. CONCLUSION: Periodontitis is a common finding among patients with acute stroke/TIA as over 80% of patients with cryptogenic stroke/TIA had periodontitis. S-hsCRP is a useful tool for detecting subclinical systemic inflammation. Copyright
BACKGROUND/AIM: Chronic infectious diseases are believed to increase the risk of stroke. We aimed to evaluate the prevalence of periodontal disease and its association with systemic inflammatory processes in patients suffering an acute stroke/transient ischemic attack (TIA). PATIENTS AND METHODS: Altogether 36 acute stroke/TIA patients underwent clinical, laboratory and radiological examinations. The level of systemic inflammation was analyzed both with routine measurements of plasma C-reactive protein (p-CRP) and serum high-sensitivity CRP (s-hsCRP) to analyze their associations with periodontitis. The diagnostic criteria for periodontitis included increased probing depth (>4 mm) measured from four different sites, bleeding on probing, and horizontal (>1 mm), vertical (>1 mm) or apical bone loss observed on orthopantomography. RESULTS: Twenty-six (72.2%) patients were diagnosed with periodontitis. Only five of the patients with periodontitis (19.2%) had elevated p-CRP values whereas the majority, (17/26; 65.4%) had elevated s-hsCRP values (p<0.01). Absolute s-hsCRP values in patients with periodontitis (8.9±12.5 mg/l) were significantly higher than in patients without periodontitis (2.3±3.0 mg/l; p<0.05). Absolute p-CRP concentrations did not differ (2.3±5.8 vs. 2.4±5.1 mg/l; p=not significant). The total number of periodontitis findings was significantly associated with s-hsCRP values (r=1.83) but not with p-CRP values. Conversely, seventeen of the nineteen patients with elevated s-hsCRP (89.5%) indicative of systemic inflammation had periodontitis. CONCLUSION:Periodontitis is a common finding among patients with acute stroke/TIA as over 80% of patients with cryptogenic stroke/TIA had periodontitis. S-hsCRP is a useful tool for detecting subclinical systemic inflammation. Copyright
Authors: Mauro Pepi; Arturo Evangelista; Petros Nihoyannopoulos; Frank A Flachskampf; George Athanassopoulos; Paolo Colonna; Gilbert Habib; E Bernd Ringelstein; Rosa Sicari; Jose Luis Zamorano; Marta Sitges; Pio Caso Journal: Eur J Echocardiogr Date: 2010-07
Authors: Mikko Taina; Ritva Vanninen; Marja Hedman; Pekka Jäkälä; Satu Kärkkäinen; Tero Tapiola; Petri Sipola Journal: PLoS One Date: 2013-11-04 Impact factor: 3.240