OBJECTIVE: Periodontitis is a very common human infection. There is evidence that periodontitis is associated with cerebrovascular disease (CVD) and stroke. The aim of this study is to examine the relationship between periodontal disease and CVD in observational studies. METHODS: An electronic search of the English literature using PubMed was conducted. A meta-analysis of the studies reporting on the risk of stroke in patients with periodontitis was performed. RESULTS: Six prospective and seven retrospective studies met the inclusion criteria. Patients with both hemorrhagic and ischemic cerebrovascular events, fatal and nonfatal, were included. Definition of periodontitis was taken directly from included studies. Most studies have been adjusted for common cardiovascular risk factors. Separate statistical analysis was performed for prospective and retrospective studies. Overall adjusted risk of stroke in subjects with periodontitis was 1.47 times higher than in subjects without (95% confidence interval, 1.13-1.92;P = .0035) in prospective and 2.63 times (95% confidence interval, 1.59-4.33;P = .0002) in retrospective studies. The application of the trim and fill algorithm does not change the initial significant inference. CONCLUSIONS: There is evidence that periodontitis is associated with increased risk of stroke. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity of the studies as well as the differences in periodontitis definition.
OBJECTIVE:Periodontitis is a very common humaninfection. There is evidence that periodontitis is associated with cerebrovascular disease (CVD) and stroke. The aim of this study is to examine the relationship between periodontal disease and CVD in observational studies. METHODS: An electronic search of the English literature using PubMed was conducted. A meta-analysis of the studies reporting on the risk of stroke in patients with periodontitis was performed. RESULTS: Six prospective and seven retrospective studies met the inclusion criteria. Patients with both hemorrhagic and ischemic cerebrovascular events, fatal and nonfatal, were included. Definition of periodontitis was taken directly from included studies. Most studies have been adjusted for common cardiovascular risk factors. Separate statistical analysis was performed for prospective and retrospective studies. Overall adjusted risk of stroke in subjects with periodontitis was 1.47 times higher than in subjects without (95% confidence interval, 1.13-1.92;P = .0035) in prospective and 2.63 times (95% confidence interval, 1.59-4.33;P = .0002) in retrospective studies. The application of the trim and fill algorithm does not change the initial significant inference. CONCLUSIONS: There is evidence that periodontitis is associated with increased risk of stroke. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity of the studies as well as the differences in periodontitis definition.
Authors: Yago Leira; Juan Seoane; Miguel Blanco; Manuel Rodríguez-Yáñez; Bahi Takkouche; Juan Blanco; José Castillo Journal: Eur J Epidemiol Date: 2016-06-14 Impact factor: 8.082
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Authors: Dominique S Michaud; Jacques Izard; Zachary Rubin; Ingegerd Johansson; Elisabete Weiderpass; Anne Tjønneland; Anja Olsen; Kim Overvad; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Laure Dossus; Rudolf Kaaks; Verena A Katzke; Heiner Boeing; Jana Foerster; Antonia Trichopoulou; Androniki Naska; Giana Ziara; Paolo Vineis; Sara Grioni; Domenico Palli; Rosario Tumino; Amalia Mattiello; Petra H M Peeters; Peter D Siersema; Aurelio Barricarte; José-María Huerta; Esther Molina-Montes; Miren Dorronsoro; J Ramón Quirós; Eric J Duell; Bodil Ohlsson; Bengt Jeppsson; Anders Johansson; Pernilla Lif; Kay-Tee Khaw; Nick Wareham; Ruth C Travis; Tim J Key; Heinz Freisling; Talita Duarte-Salles; Magdalena Stepien; Elio Riboli; H Bas Bueno-de-Mesquita Journal: Cancer Causes Control Date: 2013-07-31 Impact factor: 2.506