Oana Mocan1, Elena Buzdugan2, Angela Cozma3, Daniel Corneliu Leucuta4, Dan Radulescu2, Lucia Maria Procopciuc5. 1. "Iuliu Hatieganu" University of Medicine and Pharmacy, Faculty of Medicine, Cluj-Napoca, Romania. 2. Department of Internal Medicine, 5 Medical Clinic, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. 3. Department of Internal Medicine, 4 Medical Clinic, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. 4. Department of Medical Informatics and Biostatistics, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania dleucuta@umfcluj.ro. 5. Department of Medical Biochemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Abstract
BACKGROUND/AIM: The renin-angiotensin-aldosterone system (RAAS) may be implicated in carotid atheromatosis (CA) development. We aimed to assess the relationship of M235T-angiotensinogen (AGT) and insertion/deletion of angiotensin conversion enzyme (I/D-ACE) genotypes with CA in patients with essential hypertension (EHT). PATIENTS AND METHODS: We determined the M235T-AGT and I/D-ACE genotypes, using PCR-RFLP methods, in 162 hypertensive subjects from three tertiary regional medical centers. The relationship between the studied RAAS gene polymorphisms and CA was assessed by multiple logistic regressions. RESULTS: Hypertensive patients carrying the MT/TT235-AGT and MT235-AGT genotypes had a 2.17-fold (p=0.033) and 2.24-fold (p=0.036) increased risk to develop CA, respectively. These genotypes, MT/TT 235-AGT (OR=2.17, p=0.033) and MT235-AGT (OR=2.24, p=0.036), remain independent risk factors for CA in hypertensive patients according to the multivariate model. CONCLUSION: There is a statistically significant association between M235T-AGT and CA, when adjusting for several confounders and controlling for hypertension. Copyright
BACKGROUND/AIM: The renin-angiotensin-aldosterone system (RAAS) may be implicated in carotid atheromatosis (CA) development. We aimed to assess the relationship of M235T-angiotensinogen (AGT) and insertion/deletion of angiotensin conversion enzyme (I/D-ACE) genotypes with CA in patients with essential hypertension (EHT). PATIENTS AND METHODS: We determined the M235T-AGT and I/D-ACE genotypes, using PCR-RFLP methods, in 162 hypertensive subjects from three tertiary regional medical centers. The relationship between the studied RAAS gene polymorphisms and CA was assessed by multiple logistic regressions. RESULTS:Hypertensivepatients carrying the MT/TT235-AGT and MT235-AGT genotypes had a 2.17-fold (p=0.033) and 2.24-fold (p=0.036) increased risk to develop CA, respectively. These genotypes, MT/TT 235-AGT (OR=2.17, p=0.033) and MT235-AGT (OR=2.24, p=0.036), remain independent risk factors for CA in hypertensivepatients according to the multivariate model. CONCLUSION: There is a statistically significant association between M235T-AGT and CA, when adjusting for several confounders and controlling for hypertension. Copyright
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Authors: Sander W van der Laan; Marten A Siemelink; Saskia Haitjema; Hassan Foroughi Asl; Ljubica Perisic; Michal Mokry; Jessica van Setten; Rainer Malik; Martin Dichgans; Bradford B Worrall; Nilesh J Samani; Heribert Schunkert; Jeanette Erdmann; Ulf Hedin; Gabrielle Paulsson-Berne; Johan L M Björkegrenn; Gert J de Borst; Folkert W Asselbergs; Folkert W den Ruijter; Paul I W de Bakker; Gerard Pasterkamp Journal: Circ Genom Precis Med Date: 2018-09