Sahin Yuceli1, Gulce Naz Yazici2, Renad Mammadov3, Halis Suleyman3, Mustafa Kaya4, Selcuk Ozdogan5. 1. Department of Neurosurgery, Neon Hospital, Erzincan, Turkey. 2. Department of Histology and Embryology, Erzincan Binali Yildirim University School of Medicine, Erzincan, Turkey. 3. Department of Pharmacology, Erzincan Binali Yildirim University School of Medicine, Erzincan, Turkey. 4. Department of Neurosurgery, Sakarya Training and Research Hospital, Sakarya, Turkey. 5. Department of Neurosurgery, Beykent University School of Medicine, Istanbul, Turkey selcukozdogan@beykent.edu.tr.
Abstract
BACKGROUND/AIM: The aim of the study was to evaluate the effect of rutin, which is a vitamin P1 flavonoid with anti-inflammatory and anti-edema effects, on traumatic brain injury (TBI) and edema in rats. MATERIALS AND METHODS: Rats were divided into 3 groups as sham group without brain trauma (SG), brain trauma without medication (BT) group and Rutin treated brain trauma (RBT) group. Fifty mg/kg rutin was administered to the RBT group once a day for three days. On the fourth day, rats were sacrificed. Extracted brain tissues were examined biochemically and histopathologically. RESULTS: We found that the levels of malondialdehyde, nuclear factor-kappa B and tumor necrosis factor-alpha decreased, and those of total glutathione increased significantly. Furthermore, rutin administration reduced pyramidal neuron degeneration and poly-morpho-nuclear-leucocyte accumulation due to trauma in brain tissue, while eliminating edema. CONCLUSION: Rutin might be effective in the treatment of TBI and TBI-related brain edema. Copyright
BACKGROUND/AIM: The aim of the study was to evaluate the effect of rutin, which is a vitamin P1flavonoid with anti-inflammatory and anti-edema effects, on traumatic brain injury (TBI) and edema in rats. MATERIALS AND METHODS:Rats were divided into 3 groups as sham group without brain trauma (SG), brain trauma without medication (BT) group and Rutin treated brain trauma (RBT) group. Fifty mg/kg rutin was administered to the RBT group once a day for three days. On the fourth day, rats were sacrificed. Extracted brain tissues were examined biochemically and histopathologically. RESULTS: We found that the levels of malondialdehyde, nuclear factor-kappa B and tumor necrosis factor-alpha decreased, and those of total glutathione increased significantly. Furthermore, rutin administration reduced pyramidal neuron degeneration and poly-morpho-nuclear-leucocyte accumulation due to trauma in brain tissue, while eliminating edema. CONCLUSION:Rutin might be effective in the treatment of TBI and TBI-related brain edema. Copyright
Authors: Magda S S Moutinho; Sofia Aragão; Diogo Carmo; Fátima Casaca; Sandra Silva; Joana Ribeiro; Hugo Sousa; Isabel Pires; Felisbina Queiroga; Bruno Colaço; Rui Medeiros; Paula A Oliveira; Carlos Lopes; Margarida M S M Bastos; Rui M Gil DA Costa Journal: Anticancer Res Date: 2018-03 Impact factor: 2.480