Literature DB >> 32866519

Hepatitis B virus biology and life cycle.

Senko Tsukuda1, Koichi Watashi2.   

Abstract

Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases. The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double-stranded DNA: rcDNA) is converted to a molecular template DNA (covalently closed circular DNA: cccDNA) to amplify a viral RNA intermediate, which is then reverse-transcribed back to viral DNA. The highly stable characteristics of cccDNA result in chronic infection and a poor rate of cure. This complex life cycle of HBV offers a variety of targets to develop antiviral agents. We provide here an update on the current knowledge of HBV biology and its life cycle, which may help to identify new antiviral targets.
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Entry; HBV; Life cycle; NTCP; Replication; cccDNA

Mesh：

Substances：

Year:  2020        PMID： 32866519     DOI： 10.1016/j.antiviral.2020.104925

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  44 in total

Review 1.  Hepatitis B virus e antigen and viral persistence.

Authors:  Kuen-Nan Tsai; Jing-Hsiung James Ou
Journal:  Curr Opin Virol       Date:  2021-10-28       Impact factor: 7.090

2.  SIRT2 Promotes HBV Transcription and Replication by Targeting Transcription Factor p53 to Increase the Activities of HBV Enhancers and Promoters.

Authors:  Dai-Qing Wu; Qiu-Ying Ding; Na-Na Tao; Ming Tan; Yuan Zhang; Fan Li; Yu-Jiao Zhou; Mei-Ling Dong; Sheng-Tao Cheng; Fang Ren; Juan Chen; Ji-Hua Ren
Journal:  Front Microbiol       Date:  2022-05-19       Impact factor: 6.064

3.  Substituted Chromen-4-one Derivatives for Treating Hepatitis B Virus Infection.

Authors:  Ram W Sabnis
Journal:  ACS Med Chem Lett       Date:  2021-02-17       Impact factor: 4.345

Review 4.  Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA Formation.

Authors:  João Diogo Dias; Nazim Sarica; Christine Neuveut
Journal:  Viruses       Date:  2021-04-26       Impact factor: 5.048

5.  A Simple and Rapid Method for Quantitative Detection of Hepatitis B Virus Drug-resistant Mutations.

Authors:  Ran Wang; Zhengde Xie
Journal:  J Clin Transl Hepatol       Date:  2021-04-16

6.  Novel Substituted 3,4-Dihydroquinazoline Derivatives for Treating Hepatitis B Virus Infection.

Authors:  Ram W Sabnis
Journal:  ACS Med Chem Lett       Date:  2021-06-04       Impact factor: 4.632

Review 7.  Unique Features of Hepatitis B Virus-Related Hepatocellular Carcinoma in Pathogenesis and Clinical Significance.

Authors:  Sheng-Han Wang; Shiou-Hwei Yeh; Pei-Jer Chen
Journal:  Cancers (Basel)       Date:  2021-05-18       Impact factor: 6.639

Review 8.  Recent Advances in Hepatitis B Treatment.

Authors:  Georgia-Myrto Prifti; Dimitrios Moianos; Erofili Giannakopoulou; Vasiliki Pardali; John E Tavis; Grigoris Zoidis
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-01

Review 9.  Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis.

Authors:  Jun Inoue; Kosuke Sato; Masashi Ninomiya; Atsushi Masamune
Journal:  Viruses       Date:  2021-06-11       Impact factor: 5.048

Review 10.  HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site.

Authors:  Dake Zhang; Ke Zhang; Urlike Protzer; Changqing Zeng
Journal:  J Clin Transl Hepatol       Date:  2021-04-25
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