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Literature DB >> 3286343

Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient.

F E Dische¹, C Wernstedt, G T Westermark, P Westermark, M B Pepys, J A Rennie, S G Gilbey, P J Watkins.

Abstract

A patient with Type 1 (insulin-dependent) diabetes mellitus developed localised amyloidosis at the sites of his injections of porcine insulin. A major amyloid fibril protein was extracted and, by means of its amino acid composition and amino acid sequence, it was shown to contain intact insulin molecules. Porcine insulin is the tenth protein and the first foreign protein to be chemically identified in human amyloid fibrils.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1988 PMID： 3286343 DOI： 10.1007/bf00276849

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

15 in total

1. Regeneration of insulin from insulin fibrils by the action of alkali.

Authors: D F WAUGH
Journal: J Am Chem Soc Date: 1948-05 Impact factor: 15.419

2. Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils.

Authors: G G Glenner; E D Eanes; H A Bladen; R P Linke; J D Termine
Journal: J Histochem Cytochem Date: 1974-12 Impact factor: 2.479

3. Islet amyloid in Type 2 (non-insulin-dependent) diabetes is related to insulin.

Authors: P Westermark; E Wilander
Journal: Diabetologia Date: 1983-05 Impact factor: 10.122

4. Amyloid P component is located on elastic fibre microfibrils in normal human tissue.

Authors: S M Breathnach; S M Melrose; B Bhogal; F C de Beer; R F Dyck; G Tennent; M M Black; M B Pepys
Journal: Nature Date: 1981-10-22 Impact factor: 49.962

5. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

Authors: P Westermark; C Wernstedt; E Wilander; D W Hayden; T D O'Brien; K H Johnson
Journal: Proc Natl Acad Sci U S A Date: 1987-06 Impact factor: 11.205

6. A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.

Authors: P Westermark; C Wernstedt; E Wilander; K Sletten
Journal: Biochem Biophys Res Commun Date: 1986-11-14 Impact factor: 3.575

7. Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease.

Authors: J R Wright; E Calkins; R L Humphrey
Journal: Lab Invest Date: 1977-03 Impact factor: 5.662

8. Amyloid nephropathy of Ostertag with special reference to renal glomerular giant cells.

Authors: S W Weiss; D L Page
Journal: Am J Pathol Date: 1973-09 Impact factor: 4.307

9. Clinical spectrum of connective tissue disease after cosmetic surgery. Observations on eighteen patients and a review of the Japanese literature.

Authors: Y Kumagai; Y Shiokawa; T A Medsger; G P Rodnan
Journal: Arthritis Rheum Date: 1984-01

10. Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.

Authors: P Westermark; C Wernstedt; T D O'Brien; D W Hayden; K H Johnson
Journal: Am J Pathol Date: 1987-06 Impact factor: 4.307

64 in total

10. Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure.

Authors: Mamta Behl; Yanshu Zhang; Wei Zheng
Journal: Cerebrospinal Fluid Res Date: 2009-09-11

Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient.

1. Regeneration of insulin from insulin fibrils by the action of alkali.

2. Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils.

3. Islet amyloid in Type 2 (non-insulin-dependent) diabetes is related to insulin.

4. Amyloid P component is located on elastic fibre microfibrils in normal human tissue.

5. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

6. A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.

7. Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease.

8. Amyloid nephropathy of Ostertag with special reference to renal glomerular giant cells.

9. Clinical spectrum of connective tissue disease after cosmetic surgery. Observations on eighteen patients and a review of the Japanese literature.

10. Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.

1. Chemical modification of insulin in amyloid fibrils.

2. The protofilament structure of insulin amyloid fibrils.

3. A systematic screen of beta(2)-microglobulin and insulin for amyloid-like segments.

4. Molecular basis for insulin fibril assembly.

5. Isolating toxic insulin amyloid reactive species that lack β-sheets and have wide pH stability.

6. Molecular modeling of the misfolded insulin subunit and amyloid fibril.

7. Guiding protein aggregation with macromolecular crowding.

8. Induction in mice of human light-chain-associated amyloidosis.

9. Insulin Fibrillization at Acidic and Physiological pH Values is Controlled by Different Molecular Mechanisms.

10. Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure.