Bader Chaarani1, Kees-Jan Kan2, Scott Mackey2, Philip A Spechler2, Alexandra Potter2, Tobias Banaschewski3, Sabina Millenet3, Arun L W Bokde4, Uli Bromberg5, Christian Büchel5, Anna Cattrell6, Patricia J Conrod7, Sylvane Desrivières6, Herta Flor8, Vincent Frouin9, Jürgen Gallinat5, Penny Gowland10, Andreas Heinz11, Bernd Ittermann12, Jean-Luc Martinot13, Frauke Nees8, Tomáš Paus14, Luise Poustka15, Michael N Smolka16, Henrik Walter11, Robert Whelan17, Argyris Stringaris18, Stephen T Higgins2, Gunter Schumann19, Hugh Garavan2, Robert R Althoff2. 1. Vermont Center on Behavior and Health, University of Vermont, Burlington. Electronic address: Bchaarani01@gmail.com. 2. Vermont Center on Behavior and Health, University of Vermont, Burlington. 3. Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 4. Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Ireland. 5. University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. 6. Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. 7. Université de Montreal, CHU Ste Justine Hospital, Canada; Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. 8. Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; School of Social Sciences, University of Mannheim, Germany. 9. Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France. 10. Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK. 11. Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany. 12. Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany. 13. Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn, Paris, France. 14. Rotman Research Institute, University of Toronto, Ontario, Canada. 15. Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Medical University of Vienna, Austria. 16. Technische Universität Dresden, Dresden, Germany. 17. University College Dublin, Ireland. 18. Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. 19. Université de Montreal, CHU Ste Justine Hospital, Canada.
Abstract
OBJECTIVE: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries. METHOD: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses. RESULTS: Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume. CONCLUSION: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.
OBJECTIVE: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries. METHOD: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses. RESULTS: Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume. CONCLUSION: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.
Authors: Prerona Mukherjee; Veronika Vilgis; Shawn Rhoads; Rajpreet Chahal; Catherine Fassbender; Ellen Leibenluft; J Faye Dixon; Murat Pakyurek; Wouter van den Bos; Stephen P Hinshaw; Amanda E Guyer; Julie B Schweitzer Journal: J Atten Disord Date: 2021-11-02 Impact factor: 3.256
Authors: Dustin Scheinost; Javid Dadashkarimi; Emily S Finn; Caroline G Wambach; Caroline MacGillivray; Alexandra L Roule; Tara A Niendam; Daniel S Pine; Melissa A Brotman; Ellen Leibenluft; Wan-Ling Tseng Journal: Neuropsychopharmacology Date: 2021-01-21 Impact factor: 7.853