Laura Sanapo1, Mary T Donofrio2,3, Homa K Ahmadzia4, Alexis C Gimovsky5, Mohamed A Mohamed6. 1. Women's Medicine Collaborative-Division of Research, The Miriam Hospital, Providence, RI, USA. laurasanapomd@gmail.com. 2. Division of Fetal and Translational Medicine, Children's National Hospital, Washington, DC, USA. 3. Division of Cardiology, Children's National Hospital, Washington, DC, USA. 4. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. 5. Women & Infants Hospital, Brown University, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Providence, RI, USA. 6. Division of Newborn Services, The George Washington University Hospital, Washington, DC, USA.
Abstract
OBJECTIVE: To examine the association of any type of maternal hypertensive disorders of pregnancy (HDP) and neonatal congenital heart diseases (CHD). STUDY DESIGN: We compared the prevalence of CHD between neonates born to mothers with HDP to those delivered to mothers without HDP among 24,525,889 hospital records of living infants, from a national database. We controlled for multiple confounding factors by using multiple logistic regression analysis. RESULTS: Infants delivered to mothers with HDP had higher prevalence of CHD compared to infants born to mothers without HDP [5.20% vs. 1.47%; aOR: 2.51(2.38-2.64), p < 0.001]. Maternal diabetes was more frequent among infants born to mothers with HDP and was independently associated with CHD [aOR 5.14 (5.04-5.23), p < 0.001]. CONCLUSION: Infants born to mothers with hypertension had almost a threefold increase in CHD compared with those born to mothers without hypertension. Further studies are needed to investigate the underlying mechanism and direction of this association.
OBJECTIVE: To examine the association of any type of maternal hypertensive disorders of pregnancy (HDP) and neonatal congenital heart diseases (CHD). STUDY DESIGN: We compared the prevalence of CHD between neonates born to mothers with HDP to those delivered to mothers without HDP among 24,525,889 hospital records of living infants, from a national database. We controlled for multiple confounding factors by using multiple logistic regression analysis. RESULTS:Infants delivered to mothers with HDP had higher prevalence of CHD compared to infants born to mothers without HDP [5.20% vs. 1.47%; aOR: 2.51(2.38-2.64), p < 0.001]. Maternal diabetes was more frequent among infants born to mothers with HDP and was independently associated with CHD [aOR 5.14 (5.04-5.23), p < 0.001]. CONCLUSION:Infants born to mothers with hypertension had almost a threefold increase in CHD compared with those born to mothers without hypertension. Further studies are needed to investigate the underlying mechanism and direction of this association.
Authors: J G Seidman; Christine E Seidman; Sarah U Morton; Alexandre C Pereira; Daniel Quiat; Felix Richter; Alexander Kitaygorodsky; Jacob Hagen; Daniel Bernstein; Martina Brueckner; Elizabeth Goldmuntz; Richard W Kim; Richard P Lifton; George A Porter; Martin Tristani-Firouzi; Wendy K Chung; Amy Roberts; Bruce D Gelb; Yufeng Shen; Jane W Newburger Journal: Circ Genom Precis Med Date: 2022-02-07