Aina Ruiz1, Queralt Ferrer2, Olga Sánchez3,4, Irene Ribera1, Silvia Arévalo1, Onofre Alomar1, Manel Mendoza1, Lluís Cabero1,3, Elena Carrerras1,3, Elisa Llurba1,3. 1. a Department of Obstetrics, Maternal-Foetal Medicine Unit , Vall d'Hebron University Hospital, Universitat Autònoma De Barcelona , Barcelona , Spain . 2. b Department of Paediatric Cardiology, Vall d'Hebron University Hospital , Universitat Autònoma De Barcelona , Barcelona , Spain . 3. c Maternal and Child Health and Development Network II (SAMID II) RD12/0026, Institute of Health Carlos III , Madrid , Spain , and. 4. d Biochemistry and Molecular Biology Research Centre for Nanomedicine, Vall D'Hebron Research Institute , Barcelona , Spain.
Abstract
INTRODUCTION: Recent studies pointed to an intrinsically angiogenic imbalance in CHD in the maternal and foetal circulation suggestive of impaired placentation. OBJECTIVES: To assess whether pregnant women with a CHD foetus are at greater risk of placenta-related complications. METHODS: Perinatal results of women with a CDH foetus were compared with those of a non-selected population followed up at our centre. Multiple pregnancies and chromosomal abnormalities were excluded from the analysis. RESULTS: About 279 pregnancies with CHD foetuses were included. Mothers were classified in three groups according to the foetal cardiac defect: 104 (37.3%) atrioventricular defect, 102 (36.5%) conotruncal anomalies and 73 (26.2%) left-ventricular outflow tract obstruction. A significantly higher incidence of pre-eclampsia was observed in the CHD group compared with the normal population (5.7% versus 1.2% p < 0.0001) [OR 5.96 (95% CI - 3.19-10.54)]. About 9.7% of foetuses with CHD had < 3rd birth weight percentile compared with 3% for the normal population [OR 3.32 (95% CI - 2.39-4.56)]. A higher incidence of stillbirth was also observed in the CHD group compared with the normal population (2.5% versus 0.4%) [OR 9.45 (95% CI - 3.35-23.3)]. CONCLUSIONS: Women carrying a foetus with CHD have a high risk of pre-eclampsia and intrauterine growth restriction. The relationship between CHD and placenta-related complications could be an encouraging topic for future research.
INTRODUCTION: Recent studies pointed to an intrinsically angiogenic imbalance in CHD in the maternal and foetal circulation suggestive of impaired placentation. OBJECTIVES: To assess whether pregnant women with a CHD foetus are at greater risk of placenta-related complications. METHODS: Perinatal results of women with a CDH foetus were compared with those of a non-selected population followed up at our centre. Multiple pregnancies and chromosomal abnormalities were excluded from the analysis. RESULTS: About 279 pregnancies with CHD foetuses were included. Mothers were classified in three groups according to the foetal cardiac defect: 104 (37.3%) atrioventricular defect, 102 (36.5%) conotruncal anomalies and 73 (26.2%) left-ventricular outflow tract obstruction. A significantly higher incidence of pre-eclampsia was observed in the CHD group compared with the normal population (5.7% versus 1.2% p < 0.0001) [OR 5.96 (95% CI - 3.19-10.54)]. About 9.7% of foetuses with CHD had < 3rd birth weight percentile compared with 3% for the normal population [OR 3.32 (95% CI - 2.39-4.56)]. A higher incidence of stillbirth was also observed in the CHD group compared with the normal population (2.5% versus 0.4%) [OR 9.45 (95% CI - 3.35-23.3)]. CONCLUSIONS:Women carrying a foetus with CHD have a high risk of pre-eclampsia and intrauterine growth restriction. The relationship between CHD and placenta-related complications could be an encouraging topic for future research.
Authors: Vanessa R Kay; Matthew T Rätsep; Lindsay S Cahill; Andrew F Hickman; Bruno Zavan; Margaret E Newport; Jacob Ellegood; Christine L Laliberte; James N Reynolds; Peter Carmeliet; Chandrakant Tayade; John G Sled; B Anne Croy Journal: Physiol Genomics Date: 2018-08-17 Impact factor: 3.107
Authors: Camilla Omann; Camilla Nyboe; Rasmus Kristensen; Andreas Ernst; Cecilia Høst Ramlau-Hansen; Charlotte Rask; Ann Tabor; J William Gaynor; Vibeke E Hjortdal Journal: Eur Heart J Open Date: 2022-04-21
Authors: Laura Sanapo; Mary T Donofrio; Homa K Ahmadzia; Alexis C Gimovsky; Mohamed A Mohamed Journal: J Perinatol Date: 2020-08-28 Impact factor: 2.521
Authors: A E L van Nisselrooij; F A R Jansen; N van Geloven; I H Linskens; E Pajkrt; S-A Clur; L A Rammeloo; L Rozendaal; J M M van Lith; N A Blom; M C Haak Journal: Ultrasound Obstet Gynecol Date: 2019-12-27 Impact factor: 7.299
Authors: Jack Rychik; Donna Goff; Eileen McKay; Antonio Mott; Zhiyun Tian; Daniel J Licht; J William Gaynor Journal: Pediatr Cardiol Date: 2018-05-04 Impact factor: 1.655
Authors: I Ribera; A Ruiz; O Sánchez; E Eixarch; E Antolín; E Gómez-Montes; M Pérez-Cruz; M Cruz-Lemini; M Sanz-Cortés; S Arévalo; Q Ferrer; E Vázquez; L Vega; P Dolader; A Montoliu; H Boix; R V Simões; N Masoller; J Sánchez-de-Toledo; M Comas; J M Bartha; A Galindo; J M Martínez; L Gómez-Roig; F Crispi; O Gómez; E Carreras; L Cabero; E Gratacós; E Llurba Journal: BMC Pediatr Date: 2019-09-10 Impact factor: 2.125