Younghoon Kwon1, Sara Mariani2, Michelle Reid2, David Jacobs3, Joao Lima4, Vishesh Kapur5, Naresh Punjabi4, Susan Redline2. 1. Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: kwonx208@umn.edu. 2. Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. 3. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA. 4. Department of Medicine, Johns Hopkins University, Baltimore, MA, USA. 5. Department of Medicine, University of Washington, Seattle, WA, USA.
Abstract
BACKGROUND: Lung to finger circulation time (LFCT) measured from sleep studies may represent a novel physiologic marker for cardiovascular risk in patients with sleep disordered breathing (SDB). We hypothesized that sleep study-derived LFCT would improve risk classification of markers of subclinical cardiovascular disease. METHODS: We included participants in the Multi-Ethnic Study of Atherosclerosis (MESA) Sleep cohort with moderate-severe SDB (apnea hypopnea index [AHI] ≥ 15/hr) (N = 598). RESULTS: Those with average LFCT above the median (19.4 s) (vs. shorter LFCT) tended to be older, more obese and male. In multivariable analysis, no significant associations were found between average LFCT and subclinical cardiovascular markers including coronary artery calcium, carotid intima-media thickness or left ventricular hypertrophy. However, there was modest improvement in risk classification of coronary artery calcification as compared with AHI alone when average LFCT was added to AHI (C statistics 0.53 vs. 0.62, p = 0.0066). CONCLUSIONS: In conclusion, LFCT may be a useful addition to conventional SDB metrics to improve cardiovascular risk assessment.
BACKGROUND: Lung to finger circulation time (LFCT) measured from sleep studies may represent a novel physiologic marker for cardiovascular risk in patients with sleep disordered breathing (SDB). We hypothesized that sleep study-derived LFCT would improve risk classification of markers of subclinical cardiovascular disease. METHODS: We included participants in the Multi-Ethnic Study of Atherosclerosis (MESA) Sleep cohort with moderate-severe SDB (apnea hypopnea index [AHI] ≥ 15/hr) (N = 598). RESULTS: Those with average LFCT above the median (19.4 s) (vs. shorter LFCT) tended to be older, more obese and male. In multivariable analysis, no significant associations were found between average LFCT and subclinical cardiovascular markers including coronary artery calcium, carotid intima-media thickness or left ventricular hypertrophy. However, there was modest improvement in risk classification of coronary artery calcification as compared with AHI alone when average LFCT was added to AHI (C statistics 0.53 vs. 0.62, p = 0.0066). CONCLUSIONS: In conclusion, LFCT may be a useful addition to conventional SDB metrics to improve cardiovascular risk assessment.
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