| Literature DB >> 32839538 |
Mariolina Bruno1, Simone Kersten2,3, Judith M Bain4, Martin Jaeger2, Diletta Rosati2, Michael D Kruppa5, Douglas W Lowman5, Peter J Rice6, Bridget Graves5, Zuchao Ma5, Yue Ning Jiao5, Anuradha Chowdhary7, George Renieris8, Frank L van de Veerdonk2,9, Bart-Jan Kullberg2,9, Evangelos J Giamarellos-Bourboulis8, Alexander Hoischen2,3, Neil A R Gow4,10, Alistair J P Brown4,10, Jacques F Meis9,11,12, David L Williams5, Mihai G Netea13,14.
Abstract
Candida auris is among the most important emerging fungal pathogens, yet mechanistic insights into its immune recognition and control are lacking. Here, we integrate transcriptional and functional immune-cell profiling to uncover innate defence mechanisms against C. auris. C. auris induces a specific transcriptome in human mononuclear cells, a stronger cytokine response compared with Candida albicans, but a lower macrophage lysis capacity. C. auris-induced innate immune activation is mediated through the recognition of C-type lectin receptors, mainly elicited by structurally unique C. auris mannoproteins. In in vivo experimental models of disseminated candidiasis, C. auris was less virulent than C. albicans. Collectively, these results demonstrate that C. auris is a strong inducer of innate host defence, and identify possible targets for adjuvant immunotherapy.Entities:
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Year: 2020 PMID： 32839538 PMCID： PMC9204844 DOI： 10.1038/s41564-020-0780-3
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 30.964