| Literature DB >> 328390 |
I Lowy, C Bona, R Ciorbaru, L Chedid.
Abstract
The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with a strong antigen (heterologous red blood cells) or even with a weak immunogen such as theta alloantigen. However, in contrast to LPS, NWSM administered to mice failed to induce in vivo proliferation of lymphocytes, polyclonal activation and PFC against syngeneic bromelain-treated erythrocytes and thymocytes. It is possible therefore, that different mechanisms may be responsible for adjuvant activity of NWSM and LPS.Entities:
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Year: 1977 PMID： 328390 PMCID： PMC1445450
Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397