Inger Utne1, Bruce A Cooper2, Christine Ritchie3, Melisa Wong4, Laura B Dunn5, Borghild Loyland1, Ellen Karine Grov1, Marilyn J Hammer6, Steven M Paul2, Jon D Levine4, Yvette P Conley7, Kord M Kober2, Christine Miaskowski8. 1. Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway. 2. School of Nursing, University of California, San Francisco, CA, USA. 3. Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital Morgan Institute, Boston, MA, USA. 4. School of Medicine, University of California, San Francisco, CA, USA. 5. School of Medicine, Stanford University, Stanford, CA, USA. 6. The Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana Farber Cancer Institute, Boston, MA, USA. 7. School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. 8. School of Nursing, University of California, San Francisco, CA, USA. Electronic address: chris.miaskowski@ucsf.edu.
Abstract
PURPOSE: Older adults receiving cancer chemotherapy are at increased risk for decrements in physical (PF) and cognitive (CF) function. OBJECTIVES: Study identified subgroups of patients with distinct PF and CF profiles; risk factors associated with subgroup membership; and impact of subgroup membership on quality of life (QOL). METHODS: In 366 older oncology patients, PF and CF were assessed using the Physical Component Summary (PCS) of the SF-12 and Attentional Function Index, respectively. Latent profile analysis was used to identify subgroups of older patients with distinct PF/CF profiles. RESULTS: Three distinct PF/CF profiles were identified (i.e., Very Low PF + Moderate CF (15.6%); Low PF + Low CF (39.3%), Normal PF + Normal CF (45.1%)). Compared to the both Normal class, patients in the other two classes had a lower functional status, a worse comorbidity profile, and were less likely to exercise on a regular basis. Compared to the Both Normal class, patients in the Both Low class were less likely to be married/partnered, more likely to live alone, less likely to be employed, and more likely to report depression and back pain. Compared to the other two classes, patients in the Both Low class had a lower annual household income and were receiving chemotherapy with a worse toxicity profile. CONCLUSION: First study to use a person-centered analytic approach to identify subgroups of older adults with distinct PF/CF profiles. Fifty-five percent of the older adults had statistically significant and clinically meaningful decrements in both PF AND CF that had negative effects on all aspects of QOL.
PURPOSE: Older adults receiving cancer chemotherapy are at increased risk for decrements in physical (PF) and cognitive (CF) function. OBJECTIVES: Study identified subgroups of patients with distinct PF and CF profiles; risk factors associated with subgroup membership; and impact of subgroup membership on quality of life (QOL). METHODS: In 366 older oncology patients, PF and CF were assessed using the Physical Component Summary (PCS) of the SF-12 and Attentional Function Index, respectively. Latent profile analysis was used to identify subgroups of older patients with distinct PF/CF profiles. RESULTS: Three distinct PF/CF profiles were identified (i.e., Very Low PF + Moderate CF (15.6%); Low PF + Low CF (39.3%), Normal PF + Normal CF (45.1%)). Compared to the both Normal class, patients in the other two classes had a lower functional status, a worse comorbidity profile, and were less likely to exercise on a regular basis. Compared to the Both Normal class, patients in the Both Low class were less likely to be married/partnered, more likely to live alone, less likely to be employed, and more likely to report depression and back pain. Compared to the other two classes, patients in the Both Low class had a lower annual household income and were receiving chemotherapy with a worse toxicity profile. CONCLUSION: First study to use a person-centered analytic approach to identify subgroups of older adults with distinct PF/CF profiles. Fifty-five percent of the older adults had statistically significant and clinically meaningful decrements in both PF AND CF that had negative effects on all aspects of QOL.
Authors: Doris L van Abbema; Marjan van den Akker; Maryska L Janssen-Heijnen; Franchette van den Berkmortel; Ann Hoeben; Judith de Vos-Geelen; Frank Buntinx; Jos Kleijnen; Vivianne C G Tjan-Heijnen Journal: J Geriatr Oncol Date: 2018-04-26 Impact factor: 3.599
Authors: Rachael E Docking; Jane Fleming; Carol Brayne; Jun Zhao; Gary J Macfarlane; Gareth T Jones Journal: Rheumatology (Oxford) Date: 2011-05-23 Impact factor: 7.580
Authors: Manuel Montero-Odasso; Quincy J Almeida; Louis Bherer; Amer M Burhan; Richard Camicioli; Julien Doyon; Sarah Fraser; Susan Muir-Hunter; Karen Z H Li; Teresa Liu-Ambrose; William McIlroy; Laura Middleton; José A Morais; Ryota Sakurai; Mark Speechley; Akshya Vasudev; Olivier Beauchet; Jeffrey M Hausdorff; Caterina Rosano; Stephanie Studenski; Joe Verghese Journal: J Gerontol A Biol Sci Med Sci Date: 2019-05-16 Impact factor: 6.053