Literature DB >> 3283124

Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor.

R Kageyama1, G T Merlino, I Pastan.   

Abstract

We have studied in vitro transcription of the human epidermal growth factor (EGF) receptor proto-oncogene using nuclear extracts of A431 human epidermoid carcinoma cells, which overproduce the EGF receptor. With the in vitro system we found that Sp1 and other trans-acting factors bound to the EGF receptor promoter regions and are required for maximal expression. Fractionation showed that a DEAE-Sepharose fraction (BA) contained a novel factor, which specifically stimulated EGF receptor transcription 5- to 10-fold. The molecular mass of the native form of the factor is about 270-kDa based on its migration on Sephacryl S-300. This factor may activate transcription of the proto-oncogene through a weak or indirect interaction with the DNA template.

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Year:  1988        PMID： 3283124

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  42 in total

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Authors:  N P Bates; H C Hurst
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-04       Impact factor: 2.673

2.  Expression of transforming growth factor alpha in human tissues: immunohistochemical study and northern blot analysis.

Authors:  W Yasui; Z Q Ji; H Kuniyasu; A Ayhan; H Yokozaki; H Ito; E Tahara
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

3.  Regulation of epidermal growth factor receptor expression in normal and transformed keratinocytes.

Authors:  M F te Pas; P M van Bergen en Henegouwen; J Boonstra; M Ponec
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

4.  Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene.

Authors:  L G Hudson; K L Thompson; J Xu; G N Gill
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

5.  Modulation of epidermal growth factor receptor proto-oncogene transcription by a promoter site sensitive to S1 nuclease.

Authors:  A C Johnson; Y Jinno; G T Merlino
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

6.  EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas.

Authors:  Parsa Erfani; Jessica Tome-Garcia; Peter Canoll; Fiona Doetsch; Nadejda M Tsankova
Journal:  Epigenetics       Date:  2015-05-21       Impact factor: 4.528

7.  Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.

Authors:  J H Ludes-Meyers; M A Subler; C V Shivakumar; R M Munoz; P Jiang; J E Bigger; D R Brown; S P Deb; S Deb
Journal:  Mol Cell Biol       Date:  1996-11       Impact factor: 4.272

8.  Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.

Authors:  Emily J Faivre; Andrea R Daniel; Christopher J Hillard; Carol A Lange
Journal:  Mol Endocrinol       Date:  2008-01-17

9.  The pyrimidine/purine-biased region of the epidermal growth factor receptor gene is sensitive to S1 nuclease and may form an intramolecular triplex.

Authors:  M Kato; J Kudoh; N Shimizu
Journal:  Biochem J       Date:  1990-05-15       Impact factor: 3.857

10.  Localization of human epidermal growth factor receptor in cervical intraepithelial neoplasias.

Authors:  A Göppinger; F M Wittmaack; H O Wintzer; H Ikenberg; T Bauknecht
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553
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