Dushyant Kumar1, Ravi Prakash Reddy Nanga1, Deepa Thakuri1, Neil Wilson2, Abigail Cember1, Melissa Lynne Martin3, Dan Zhu4, Russell T Shinohara3, Qin Qin5,6, Hari Hariharan1, Ravinder Reddy1. 1. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 2. Siemens Medical Solutions USA Inc., Malvern, Pennsylvania, USA. 3. Penn Statistics in Imaging and Visualization Center, Department of Biostatistics and Epidemiology, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. 4. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 5. The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 6. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
Abstract
PURPOSE: Two-dimensional creatine CEST (2D-CrCEST), with a slice thickness of 10-20 mm and temporal resolution (τRes ) of about 30 seconds, has previously been shown to capture the creatine-recovery kinetics in healthy controls and in patients with abnormal creatine-kinase kinetics following the mild plantar flexion exercise. Since the distribution of disease burden may vary across the muscle length for many musculoskeletal disorders, there is a need to increase coverage in the slice-encoding direction. Here, we demonstrate the feasibility of 3D-CrCEST with τRes of about 30 seconds, and propose an improved voxel-wise B 1 + -calibration approach for CrCEST. METHODS: The current 7T study with enrollment of 5 volunteers involved collecting the baseline CrCEST imaging for the first 2 minutes, followed by 2 minutes of plantar flexion exercise and then 8 minutes of postexercise CrCEST imaging, to detect the temporal evolution of creatine concentration following exercise. RESULTS: Very good repeatability of 3D-CrCEST findings for activated muscle groups on an intraday and interday basis was established, with coefficient of variance of creatine recovery constants (τCr ) being 7%-15.7%, 7.5%, and 5.8% for lateral gastrocnemius, medial gastrocnemius, and peroneus longus, respectively. We also established a good intraday and interday scan repeatability for 3D-CrCEST and also showed good correspondence between τCr measurements using 2D-CrCEST and 3D-CrCEST acquisitions. CONCLUSION: In this study, we demonstrated for the first time the feasibility and the repeatability of the 3D-CrCEST method in calf muscle with improved B 1 + correction to measure creatine-recovery kinetics within a large 3D volume of calf muscle.
PURPOSE: Two-dimensional creatine CEST (2D-CrCEST), with a slice thickness of 10-20 mm and temporal resolution (τRes ) of about 30 seconds, has previously been shown to capture the creatine-recovery kinetics in healthy controls and in patients with abnormal creatine-kinase kinetics following the mild plantar flexion exercise. Since the distribution of disease burden may vary across the muscle length for many musculoskeletal disorders, there is a need to increase coverage in the slice-encoding direction. Here, we demonstrate the feasibility of 3D-CrCEST with τRes of about 30 seconds, and propose an improved voxel-wise B 1 + -calibration approach for CrCEST. METHODS: The current 7T study with enrollment of 5 volunteers involved collecting the baseline CrCEST imaging for the first 2 minutes, followed by 2 minutes of plantar flexion exercise and then 8 minutes of postexercise CrCEST imaging, to detect the temporal evolution of creatine concentration following exercise. RESULTS: Very good repeatability of 3D-CrCEST findings for activated muscle groups on an intraday and interday basis was established, with coefficient of variance of creatine recovery constants (τCr ) being 7%-15.7%, 7.5%, and 5.8% for lateral gastrocnemius, medial gastrocnemius, and peroneus longus, respectively. We also established a good intraday and interday scan repeatability for 3D-CrCEST and also showed good correspondence between τCr measurements using 2D-CrCEST and 3D-CrCEST acquisitions. CONCLUSION: In this study, we demonstrated for the first time the feasibility and the repeatability of the 3D-CrCEST method in calf muscle with improved B 1 + correction to measure creatine-recovery kinetics within a large 3D volume of calf muscle.
Authors: Mark A Griswold; Peter M Jakob; Robin M Heidemann; Mathias Nittka; Vladimir Jellus; Jianmin Wang; Berthold Kiefer; Axel Haase Journal: Magn Reson Med Date: 2002-06 Impact factor: 4.668
Authors: Mohammad Haris; Anup Singh; Kejia Cai; Feliks Kogan; Jeremy McGarvey; Catherine Debrosse; Gerald A Zsido; Walter R T Witschey; Kevin Koomalsingh; James J Pilla; Julio A Chirinos; Victor A Ferrari; Joseph H Gorman; Hari Hariharan; Robert C Gorman; Ravinder Reddy Journal: Nat Med Date: 2014-01-12 Impact factor: 53.440
Authors: Ladislav Valkovič; Marek Chmelík; Ivica Just Kukurová; Michaela Jakubová; Monika Christina Kipfelsberger; Patrik Krumpolec; Marjeta Tušek Jelenc; Wolfgang Bogner; Martin Meyerspeer; Jozef Ukropec; Ivan Frollo; Barbara Ukropcová; Siegfried Trattnig; Martin Krššák Journal: NMR Biomed Date: 2014-09-09 Impact factor: 4.044
Authors: Ravi Prakash Reddy Nanga; Catherine DeBrosse; Dushyant Kumar; David Roalf; Brendan McGeehan; Kevin D'Aquilla; Arijitt Borthakur; Hari Hariharan; Damodara Reddy; Mark Elliott; John A Detre; Cynthia Neill Epperson; Ravinder Reddy Journal: Magn Reson Med Date: 2018-05-25 Impact factor: 4.668
Authors: Helen L Sporkin; Toral R Patel; Yaqub Betz; Roshin Mathew; Christopher L Schumann; Craig H Meyer; Christopher M Kramer Journal: Circ Cardiovasc Imaging Date: 2022-07-19 Impact factor: 8.589
Authors: Peter C M van Zijl; Kevin Brindle; Hanzhang Lu; Peter B Barker; Richard Edden; Nirbhay Yadav; Linda Knutsson Journal: Curr Opin Chem Biol Date: 2021-07-20 Impact factor: 8.972