| Literature DB >> 32816852 |
Akihisa Hidaka1, Tabitha A Harrison2, Yin Cao3,4,5, Lori C Sakoda2,6, Richard Barfield2, Marios Giannakis7, Mingyang Song8,9,10, Amanda I Phipps2,11, Jane C Figueiredo12,13, Syed H Zaidi14, Amanda E Toland15, Efrat L Amitay16, Sonja I Berndt17, Ivan Borozan18, Andrew T Chan9,10,19,20,21,22, Steven Gallinger23, Marc J Gunter24, Mark A Guinter25, Sophia Harlid26, Heather Hampel15, Mark A Jenkins27, Yi Lin2, Victor Moreno28,29,30,31, Polly A Newcomb2,32, Reiko Nishihara33,34, Shuji Ogino20,21,33,35, Mireia Obón-Santacana28,31,36, Patrick S Parfrey37, John D Potter2, Martha L Slattery38, Robert S Steinfelder2, Caroline Y Um25, Xiaoliang Wang2, Michael O Woods39, Bethany Van Guelpen26,40, Stephen N Thibodeau41, Michael Hoffmeister16, Wei Sun2, Li Hsu2,42, Daniel D Buchanan43,44,45, Peter T Campbell25, Ulrike Peters2,11.
Abstract
Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by colorectal cancer molecular subtypes. Here, we investigate the association of fruit, vegetables, and fiber intake with four well-established colorectal cancer molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend toward decreased risk of BRAF-mutated tumors [OR 4th vs. 1st quartile = 0.82 (95% confidence interval, 0.65-1.04)] but not BRAF-wildtype tumors [1.09 (0.97-1.22); P difference as shown in case-only analysis = 0.02]. This difference was observed in case-control studies and not in cohort studies. Compared with controls, higher fiber intake showed negative association with colorectal cancer risk for cases with microsatellite stable/MSI-low, CIMP-negative, BRAF-wildtype, and KRAS-wildtype tumors (P trend range from 0.03 to 3.4e-03), which is consistent with the traditional adenoma-colorectal cancer pathway. These negative associations were stronger compared with MSI-high, CIMP-positive, BRAF-mutated, or KRAS-mutated tumors, but the differences were not statistically significant. These inverse associations for fruit and fiber intake may explain, in part, inconsistent findings between fruit or fiber intake and colorectal cancer risk that have previously been reported. SIGNIFICANCE: These analyses by colorectal cancer molecular subtypes potentially explain the inconsistent findings between dietary fruit or fiber intake and overall colorectal cancer risk that have previously been reported. ©2020 American Association for Cancer Research.Entities:
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Year: 2020 PMID： 32816852 PMCID： PMC7572895 DOI： 10.1158/0008-5472.CAN-20-0168
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701