Literature DB >> 32816732

Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants.

Vladimir Vimberg1, Jorunn Pauline Cavanagh2,3, Michaela Novotna1, Jakub Lenart1,4, Bich Nguyen Thi Ngoc1, Jana Vesela1, Maria Pain3, Marketa Koberska1, Gabriela Balikova Novotna5.   

Abstract

Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LSAP) by displacing antibiotics from the ribosome. Here, we show that expression of vga(A) variants from Staphylococcus haemolyticus is regulated by cis-regulatory RNA in response to the LSAP antibiotics by the mechanism of ribosome-mediated attenuation. The specificity of induction depends on Vga(A)-mediated resistance rather than on the sequence of the riboregulator. Fine tuning between Vga(A) activity and its expression in response to the antibiotics may contribute to the selection of more potent Vga(A) variants because newly acquired mutation can be immediately phenotypically manifested.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  ABCF proteins; Staphylococcus haemolyticuszzm321990; Vga(A); antibiotic resistance; clindamycin; lincosamides; pleuromutilins; regulation of gene expression; ribosome-mediated attenuation

Year:  2020        PMID： 32816732      PMCID： PMC7577164          DOI： 10.1128/AAC.00666-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  51 in total

1.  Rapid genotyping of methicillin-resistant Staphylococcus aureus (MRSA) isolates using miniaturised oligonucleotide arrays.

Authors:  S Monecke; R Ehricht
Journal:  Clin Microbiol Infect       Date:  2005-10       Impact factor: 8.067

2.  Characterization of methicillin-resistant Staphylococcus aureus isolates from food and food products of poultry origin in Germany.

Authors:  Andrea T Fessler; Kristina Kadlec; Melanie Hassel; Tomasz Hauschild; Christopher Eidam; Ralf Ehricht; Stefan Monecke; Stefan Schwarz
Journal:  Appl Environ Microbiol       Date:  2011-07-01       Impact factor: 4.792

3.  Detailed mutational analysis of Vga(A) interdomain linker: implication for antibiotic resistance specificity and mechanism.

Authors:  Jakub Lenart; Vladimir Vimberg; Ludmila Vesela; Jiri Janata; Gabriela Balikova Novotna
Journal:  Antimicrob Agents Chemother       Date:  2014-12-15       Impact factor: 5.191

4.  Identification of novel vga(A)-carrying plasmids and a Tn5406-like transposon in meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis of human and animal origin.

Authors:  Carmen Lozano; Carmen Aspiroz; Antonio Rezusta; Elena Gómez-Sanz; Carmen Simon; Paula Gómez; Carmelo Ortega; Maria José Revillo; Myriam Zarazaga; Carmen Torres
Journal:  Int J Antimicrob Agents       Date:  2012-08-14       Impact factor: 5.283

5.  Decreased susceptibilities to Retapamulin, Mupirocin, and Chlorhexidine among Staphylococcus aureus isolates causing skin and soft tissue infections in otherwise healthy children.

Authors:  J Chase McNeil; Kristina G Hulten; Sheldon L Kaplan; Edward O Mason
Journal:  Antimicrob Agents Chemother       Date:  2014-03-10       Impact factor: 5.191

Review 6.  Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health.

Authors:  Engeline van Duijkeren; Christina Greko; Märit Pringle; Keith Edward Baptiste; Boudewijn Catry; Helen Jukes; Miguel A Moreno; M Constança Matias Ferreira Pomba; Satu Pyörälä; Merja Rantala; Modestas Ružauskas; Pascal Sanders; Christopher Teale; E John Threlfall; Jordi Torren-Edo; Karolina Törneke
Journal:  J Antimicrob Chemother       Date:  2014-05-03       Impact factor: 5.790

7.  Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.

Authors:  Daniel R Gentry; Lynn McCloskey; Michael N Gwynn; Stephen F Rittenhouse; Nicole Scangarella; Ribhi Shawar; David J Holmes
Journal:  Antimicrob Agents Chemother       Date:  2008-10-06       Impact factor: 5.191

8.  Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics.

Authors:  Elizeth Lopes; Teresa Conceição; Laurent Poirel; Hermínia de Lencastre; Marta Aires-de-Sousa
Journal:  PLoS One       Date:  2019-11-20       Impact factor: 3.240

9.  The multidrug ABC transporter BmrC/BmrD of Bacillus subtilis is regulated via a ribosome-mediated transcriptional attenuation mechanism.

Authors:  Ewoud Reilman; Ruben A T Mars; Jan Maarten van Dijl; Emma L Denham
Journal:  Nucleic Acids Res       Date:  2014-09-12       Impact factor: 16.971

10.  Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.

Authors:  Louise Kime; Christopher P Randall; Frank I Banda; Francesc Coll; John Wright; Joseph Richardson; Joanna Empel; Julian Parkhill; Alex J O'Neill
Journal:  mBio       Date:  2019-10-29       Impact factor: 7.867
View more
  5 in total

1.  Gene rppA co-regulated by LRR, SigA, and CcpA mediates antibiotic resistance in Bacillus thuringiensis.

Authors:  Xia Cai; Xuelian Li; Jiaxin Qin; Yizhuo Zhang; Bing Yan; Jun Cai
Journal:  Appl Microbiol Biotechnol       Date:  2022-07-30       Impact factor: 5.560

2.  Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis.

Authors:  Marketa Koberska; Ludmila Vesela; Vladimir Vimberg; Jakub Lenart; Jana Vesela; Zdenek Kamenik; Jiri Janata; Gabriela Balikova Novotna
Journal:  mBio       Date:  2021-09-07       Impact factor: 7.867

3.  Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.

Authors:  Caillan Crowe-McAuliffe; Victoriia Murina; Kathryn Jane Turnbull; Marje Kasari; Merianne Mohamad; Christine Polte; Hiraku Takada; Karolis Vaitkevicius; Jörgen Johansson; Zoya Ignatova; Gemma C Atkinson; Alex J O'Neill; Vasili Hauryliuk; Daniel N Wilson
Journal:  Nat Commun       Date:  2021-06-11       Impact factor: 14.919

Review 4.  Ribosome Protection Proteins-"New" Players in the Global Arms Race with Antibiotic-Resistant Pathogens.

Authors:  Rya Ero; Xin-Fu Yan; Yong-Gui Gao
Journal:  Int J Mol Sci       Date:  2021-05-19       Impact factor: 5.923

Review 5.  Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition.

Authors:  Abolfazl Dashtbani-Roozbehani; Melissa H Brown
Journal:  Antibiotics (Basel)       Date:  2021-12-07
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.