Literature DB >> 18838584

Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.

Daniel R Gentry1, Lynn McCloskey, Michael N Gwynn, Stephen F Rittenhouse, Nicole Scangarella, Ribhi Shawar, David J Holmes.   

Abstract

Retapamulin MICs of > or =2 microg/ml were noted for 6 of 5,676 S. aureus recent clinical isolates evaluated. The ABC proteins VgaAv and VgaA were found to be responsible for the reduced susceptibility to pleuromutilins exhibited by these six isolates.

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Year:  2008        PMID： 18838584      PMCID： PMC2592886          DOI： 10.1128/AAC.00915-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Characterization of a variant of vga(A) conferring resistance to streptogramin A and related compounds.

Authors:  J Haroche; J Allignet; C Buchrieser; N El Solh
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

2.  Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes.

Authors:  Kang Yan; Lenore Madden; Anthony E Choudhry; Christine S Voigt; Robert A Copeland; Richard R Gontarek
Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

3.  Genetic analysis of epidermin biosynthetic genes and epidermin-negative mutants of Staphylococcus epidermidis.

Authors:  J Augustin; R Rosenstein; B Wieland; U Schneider; N Schnell; G Engelke; K D Entian; F Götz
Journal:  Eur J Biochem       Date:  1992-03-15

4.  Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci.

Authors:  Olivier Chesneau; Heidi Ligeret; Negin Hosan-Aghaie; Anne Morvan; Elie Dassa
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

5.  A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.

Authors:  G Novotna; J Janata
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

6.  The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage.

Authors:  B N Kreiswirth; S Löfdahl; M J Betley; M O'Reilly; P M Schlievert; M S Bergdoll; R P Novick
Journal:  Nature       Date:  1983 Oct 20-26       Impact factor: 49.962

Review 7.  Phylogenetic and functional classification of ATP-binding cassette (ABC) systems.

Authors:  Philippe Bouige; David Laurent; Linda Piloyan; Elie Dassa
Journal:  Curr Protein Pept Sci       Date:  2002-10       Impact factor: 3.272

Review 8.  Retapamulin: a new topical antibiotic for the treatment of uncomplicated skin infections.

Authors:  Lawrence Charles Parish; Jennifer L Parish
Journal:  Drugs Today (Barc)       Date:  2008-02       Impact factor: 2.245

9.  PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori.

Authors:  N S Akopyants; A Fradkov; L Diatchenko; J E Hill; P D Siebert; S A Lukyanov; E D Sverdlov; D E Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

10.  In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes.

Authors:  G Novotná; J Spízek; J Janata
Journal:  Folia Microbiol (Praha)       Date:  2007       Impact factor: 2.629
  10 in total
  22 in total

1.  Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin.

Authors:  Hongbin Si; Wan-Jiang Zhang; Shengbo Chu; Xiu-Mei Wang; Lei Dai; Xin Hua; Zhimin Dong; Stefan Schwarz; Siguo Liu
Journal:  Antimicrob Agents Chemother       Date:  2015-08-31       Impact factor: 5.191

2.  Resistance Genes Underlying the LSA Phenotype of Staphylococcal Isolates from France.

Authors:  Sophie Tessé; François Trueba; Nicolas Berthet; Chloé Hot; Olivier Chesneau
Journal:  Antimicrob Agents Chemother       Date:  2013-06-24       Impact factor: 5.191

3.  New transposon Tn6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene.

Authors:  Sybille Schwendener; Vincent Perreten
Journal:  Antimicrob Agents Chemother       Date:  2011-07-18       Impact factor: 5.191

4.  Detailed mutational analysis of Vga(A) interdomain linker: implication for antibiotic resistance specificity and mechanism.

Authors:  Jakub Lenart; Vladimir Vimberg; Ludmila Vesela; Jiri Janata; Gabriela Balikova Novotna
Journal:  Antimicrob Agents Chemother       Date:  2014-12-15       Impact factor: 5.191

Review 5.  Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns.

Authors:  Deborah A Williamson; Glen P Carter; Benjamin P Howden
Journal:  Clin Microbiol Rev       Date:  2017-07       Impact factor: 26.132

6.  Ribosome-Mediated Attenuation of vga(A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants.

Authors:  Vladimir Vimberg; Jorunn Pauline Cavanagh; Michaela Novotna; Jakub Lenart; Bich Nguyen Thi Ngoc; Jana Vesela; Maria Pain; Marketa Koberska; Gabriela Balikova Novotna
Journal:  Antimicrob Agents Chemother       Date:  2020-10-20       Impact factor: 5.191

7.  Decreased susceptibilities to Retapamulin, Mupirocin, and Chlorhexidine among Staphylococcus aureus isolates causing skin and soft tissue infections in otherwise healthy children.

Authors:  J Chase McNeil; Kristina G Hulten; Sheldon L Kaplan; Edward O Mason
Journal:  Antimicrob Agents Chemother       Date:  2014-03-10       Impact factor: 5.191

8.  Expansion of a plasmid classification system for Gram-positive bacteria and determination of the diversity of plasmids in Staphylococcus aureus strains of human, animal, and food origins.

Authors:  Carmen Lozano; Lourdes García-Migura; Carmen Aspiroz; Myriam Zarazaga; Carmen Torres; Frank Møller Aarestrup
Journal:  Appl Environ Microbiol       Date:  2012-06-08       Impact factor: 4.792

Review 9.  Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.

Authors:  Stefan Schwarz; Jianzhong Shen; Kristina Kadlec; Yang Wang; Geovana Brenner Michael; Andrea T Feßler; Birte Vester
Journal:  Cold Spring Harb Perspect Med       Date:  2016-11-01       Impact factor: 6.915

10.  Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.

Authors:  Kristina Kadlec; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2009-05-26       Impact factor: 5.191
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