| Literature DB >> 32812486 |
Guo Ye1,2, Fangyuan Bao1,2, Xianzhu Zhang1,2, Zhe Song1,2, Youguo Liao1,2, Yang Fei1, Varitsara Bunpetch1,2, Boon Chin Heng3, Weiliang Shen1,2,4,5, Hua Liu1,2,5, Jing Zhou1,2,5, Hongwei Ouyang1,2,4,5.
Abstract
The global incidence of bone tissue injuries has been increasing rapidly in recent years, making it imperative to develop suitable bone grafts for facilitating bone tissue regeneration. It has been demonstrated that nanomaterials/nanocomposites scaffolds can more effectively promote new bone tissue formation compared with micromaterials. This may be attributed to their nanoscaled structural and topological features that better mimic the physiological characteristics of natural bone tissue. In this review, we examined the current applications of various nanomaterial/nanocomposite scaffolds and different topological structures for bone tissue engineering, as well as the underlying mechanisms of regeneration. The potential risks and toxicity of nanomaterials will also be critically discussed. Finally, some considerations for the clinical applications of nanomaterials/nanocomposites scaffolds for bone tissue engineering are mentioned.Entities:
Keywords: bone tissue engineering; nanomaterials; nanotopography; scaffold
Mesh：
Year: 2020 PMID： 32812486 DOI： 10.2217/nnm-2020-0112
Source DB: PubMed Journal: Nanomedicine (Lond) ISSN： 1743-5889 Impact factor: 5.307