| Literature DB >> 32812049 |
Christophe Guervilly1,2, Stephane Burtey3,4, Florence Sabatier4,5,6, Raphaël Cauchois4,7, Guillaume Lano3,4, Evelyne Abdili5, Florence Daviet3, Laurent Arnaud5, Philippe Brunet3,4, Sami Hraiech1,2, Noémie Jourde-Chiche3,4, Marie Koubi7, Romaric Lacroix4,5, Léa Pietri8, Yaël Berda5, Thomas Robert3,4, Clara Degioanni6, Mélanie Velier4,5, Laurent Papazian1,2, Gilles Kaplanski4,7, Françoise Dignat-George4,5.
Abstract
Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.Entities:
Keywords: COVID-19; circulating endothelial cells; endothelial injury
Mesh：
Substances：
Year: 2020 PMID： 32812049 PMCID： PMC7454721 DOI： 10.1093/infdis/jiaa528
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226