| Literature DB >> 34945111 |
Ivo Udovicic1,2, Ivan Stanojevic2,3, Dragan Djordjevic1,2, Snjezana Zeba1,2, Goran Rondovic1,2, Tanja Abazovic1, Srdjan Lazic2,4, Danilo Vojvodic2,3, Kendrick To5, Dzihan Abazovic6, Wasim Khan5, Maja Surbatovic1,2.
Abstract
Immune cells and mediators play a crucial role in the critical care setting but are understudied. This review explores the concept of sepsis and/or injury-induced immunosuppression and immuno-inflammatory response in COVID-19 and reiterates the need for more accurate functional immunomonitoring of monocyte and neutrophil function in these critically ill patients. in addition, the feasibility of circulating and cell-surface immune biomarkers as predictors of infection and/or outcome in critically ill patients is explored. It is clear that, for critically ill, one size does not fit all and that immune phenotyping of critically ill patients may allow the development of a more personalized approach with tailored immunotherapy for the specific patient. In addition, at this point in time, caution is advised regarding the quality of evidence of some COVID-19 studies in the literature.Entities:
Keywords: COVID-19; biomarkers; critical illness; immunologic; immunosuppression; immunotherapy; monitoring; sepsis; therapy; trauma
Year: 2021 PMID： 34945111 PMCID： PMC8706110 DOI： 10.3390/jcm10245815
Source DB: PubMed Journal: J Clin Med ISSN： 2077-0383 Impact factor: 4.241