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Literature DB >> 3281134

Chromatographic separation of enantiomers.

Abstract

In this paper a review is presented on the chromatographic analysis of enantiomers with special attention to high pressure liquid chromatography. Also, some examples of resolution of racemates by thin layer chromatography and gas chromatography are given. The various procedures in the surveyed literature have been divided into three main classes: procedures with formation of diastereomeric compounds prior to the chromatographic separation, procedures in which a chiral mobile phase is used, and procedures with the use of a chiral stationary phase. These methods are subdivided and some examples of their application to drugs and related compounds are presented.

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Year: 1988 PMID： 3281134 DOI： 10.1007/bf01966428

Source DB: PubMed Journal: Pharm Weekbl Sci ISSN： 0167-6555

18 in total

1. Chromatographic resolution of enantiomers using albumin as complexing agent in the mobile phase.

Authors: C Pettersson; T Arvidsson; A L Karlsson; I Marle
Journal: J Pharm Biomed Anal Date: 1986 Impact factor: 3.935

2. Separation of acebutolol and diacetolol diastereomers by reversed-phase high-performance liquid chromatography.

Authors: A A Gulaid; G W Houghton; A R Boobis
Journal: J Chromatogr Date: 1985-01-18

3. Determination of the enantiomeric purity of levodopa, methyldopa, carbidopa and tryptophan by use of chiral mobile phase high-performance liquid chromatography.

Authors: L R Gelber; J L Neumeyer
Journal: J Chromatogr Date: 1983-03-04

4. A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers.

Authors: W H Pirkle; M H Hyun; A Tsipouras; B C Hamper; B Banks
Journal: J Pharm Biomed Anal Date: 1984 Impact factor: 3.935

5. Monitoring of S- and R-tocainide in human plasma after heptafluorobutyrylation, separation on Chirasil-Val and electron-capture detection.

Authors: A M Antonsson; O Gyllenhaal; K Kylberg-Hanssen; L Johansson; J Vessman
Journal: J Chromatogr Date: 1984-06-08

6. Separation, isolation and identification of optical isomers of 1,4-benzodiazepine glucuronides from biological fluids by reversed-phase high-performance liquid chromatography.

Authors: H Mascher; V Nitsche; H Schütz
Journal: J Chromatogr Date: 1984-03-09

7. Application of a radial compression column to the high-performance liquid chromatographic separation of the enantiomers of some 2-arylpropionic acids as their diastereoisomeric s-(-)-1-(naphthen-1-yl)ethylamines.

Authors: A J Hutt; S Fournel; J Caldwell
Journal: J Chromatogr Date: 1986-06-13

8. High-performance liquid chromatographic separation of the enantiomers of anti-inflammatory 2-arylpropionates: suitability of the method for in vitro metabolic studies.

Authors: J M Maître; G Boss; B Testa
Journal: J Chromatogr Date: 1984-09-21