Literature DB >> 32808035

Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy.

Shyra Wilde1, Katherine L Olivares1,2, Victor Nizet3,4,5, Hal M Hoffman4,5, Suhas Radhakrishna4,5, Christopher N LaRock1,6,7.   

Abstract

Invasive group A Streptococcus (GAS) in immunocompetent individuals is largely linked to hypervirulent strains. Congenital immunodeficiencies and those acquired from chronic disease or immunosuppressant drugs also increase risk of severe illness. We recovered GAS from the blood of a patient receiving a biologic inhibitor of interleukin 6 (IL-6). Growth of this serotype M4 isolate in human blood or a murine bacteremia model was promoted by interleukin 1 or IL-6 inhibition. Hyperinvasive M1T1 GAS was unaffected by IL-6 in both models. These findings based on a natural experiment introduce IL-6 signaling deficiencies as a risk factor for invasive GAS.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  IL-6; adverse events; group A Streptococcus; immunotherapy; sepsis

Mesh：

Substances：

Year:  2021        PMID： 32808035      PMCID： PMC8030709          DOI： 10.1093/infdis/jiaa511

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-24       Impact factor: 11.205

2.  Necrotizing fasciitis in a rheumatoid arthritis patient treated with tocilizumab.

Authors:  Marleen G H van de Sande; Eline R van Slobbe-Bijlsma
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Review 3.  Chemoprophylaxis against group A streptococcus during military training.

Authors:  Bryant J Webber; John W Kieffer; Brian K White; Anthony W Hawksworth; Paul C F Graf; Heather C Yun
Journal:  Prev Med       Date:  2018-10-26       Impact factor: 4.018

4.  Necrotizing fasciitis in a patient receiving tocilizumab for rheumatoid arthritis - Case report.

Authors:  Diana Rosa-Gonçalves; Miguel Bernardes; Lúcia Costa
Journal:  Reumatol Clin (Engl Ed)       Date:  2016-12-29

5.  Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events.

Authors:  Paul Sumby; Steve F Porcella; Andres G Madrigal; Kent D Barbian; Kimmo Virtaneva; Stacy M Ricklefs; Daniel E Sturdevant; Morag R Graham; Jaana Vuopio-Varkila; Nancy P Hoe; James M Musser
Journal:  J Infect Dis       Date:  2005-07-29       Impact factor: 5.226

6.  IL-1β is an innate immune sensor of microbial proteolysis.

Authors:  Christopher N LaRock; Jordan Todd; Doris L LaRock; Joshua Olson; Anthony J O'Donoghue; Avril A B Robertson; Matthew A Cooper; Hal M Hoffman; Victor Nizet
Journal:  Sci Immunol       Date:  2016-08-19

7.  Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production.

Authors:  Hongyan Diao; Masashi Kohanawa
Journal:  Infect Immun       Date:  2005-06       Impact factor: 3.441

8.  Effects of selective and nonselective nonsteroidal anti-inflammatory drugs on antibiotic efficacy of experimental group A streptococcal myonecrosis.

Authors:  Stephanie M Hamilton; Clifford R Bayer; Dennis L Stevens; Amy E Bryant
Journal:  J Infect Dis       Date:  2013-11-11       Impact factor: 5.226

9.  Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.

Authors:  Josef S Smolen; Andre Beaulieu; Andrea Rubbert-Roth; Cesar Ramos-Remus; Josef Rovensky; Emma Alecock; Thasia Woodworth; Rieke Alten
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10.  Detection of group A Streptococcus in tonsils from pediatric patients reveals high rate of asymptomatic streptococcal carriage.

Authors:  Amity L Roberts; Kristie L Connolly; Daniel J Kirse; Adele K Evans; Katherine A Poehling; Timothy R Peters; Sean D Reid
Journal:  BMC Pediatr       Date:  2012-01-09       Impact factor: 2.125
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  3 in total

Review 1.  Streptococcal Infections in Marine Mammals.

Authors:  Daniela Numberger; Ursula Siebert; Marcus Fulde; Peter Valentin-Weigand
Journal:  Microorganisms       Date:  2021-02-10

Review 2.  Antibiotic Treatment, Mechanisms for Failure, and Adjunctive Therapies for Infections by Group A Streptococcus.

Authors:  Anders F Johnson; Christopher N LaRock
Journal:  Front Microbiol       Date:  2021-11-04       Impact factor: 5.640

Review 3.  Playing With Fire: Proinflammatory Virulence Mechanisms of Group A Streptococcus.

Authors:  Shyra Wilde; Anders F Johnson; Christopher N LaRock
Journal:  Front Cell Infect Microbiol       Date:  2021-07-06       Impact factor: 5.293
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