Literature DB >> 32807900

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics.

Anna S Nam1,2,3, Ronan Chaligne2,3,4, Dan A Landau5,6,7,8.   

Abstract

Cancer represents an evolutionary process through which growing malignant populations genetically diversify, leading to tumour progression, relapse and resistance to therapy. In addition to genetic diversity, the cell-to-cell variation that fuels evolutionary selection also manifests in cellular states, epigenetic profiles, spatial distributions and interactions with the microenvironment. Therefore, the study of cancer requires the integration of multiple heritable dimensions at the resolution of the single cell - the atomic unit of somatic evolution. In this Review, we discuss emerging analytic and experimental technologies for single-cell multi-omics that enable the capture and integration of multiple data modalities to inform the study of cancer evolution. These data show that cancer results from a complex interplay between genetic and non-genetic determinants of somatic evolution.

Entities:  

Mesh：

Year:  2020        PMID： 32807900      PMCID： PMC8450921          DOI： 10.1038/s41576-020-0265-5

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  177 in total

1.  RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues.

Authors:  Keren Yizhak; François Aguet; Jaegil Kim; Julian M Hess; Kirsten Kübler; Jonna Grimsby; Ruslana Frazer; Hailei Zhang; Nicholas J Haradhvala; Daniel Rosebrock; Dimitri Livitz; Xiao Li; Eila Arich-Landkof; Noam Shoresh; Chip Stewart; Ayellet V Segrè; Philip A Branton; Paz Polak; Kristin G Ardlie; Gad Getz
Journal:  Science       Date:  2019-06-07       Impact factor: 47.728

2.  Lessons learned from the automatic implantable cardioverter-defibrillator: past, present and future.

Authors:  P J Troup
Journal:  J Am Coll Cardiol       Date:  1988-06       Impact factor: 24.094

3.  Portraits of an illness.

Authors:  Thomas P Duffy
Journal:  Trans Am Clin Climatol Assoc       Date:  2009

Review 4.  Resolving genetic heterogeneity in cancer.

Authors:  Samra Turajlic; Andrea Sottoriva; Trevor Graham; Charles Swanton
Journal:  Nat Rev Genet       Date:  2019-07       Impact factor: 53.242

5.  Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

Authors:  Iñigo Martincorena; Amit Roshan; Moritz Gerstung; Peter Ellis; Peter Van Loo; Stuart McLaren; David C Wedge; Anthony Fullam; Ludmil B Alexandrov; Jose M Tubio; Lucy Stebbings; Andrew Menzies; Sara Widaa; Michael R Stratton; Philip H Jones; Peter J Campbell
Journal:  Science       Date:  2015-05-22       Impact factor: 47.728

6.  Tobacco smoking and somatic mutations in human bronchial epithelium.

Authors:  Kenichi Yoshida; Kate H C Gowers; Henry Lee-Six; Deepak P Chandrasekharan; Tim Coorens; Elizabeth F Maughan; Kathryn Beal; Andrew Menzies; Fraser R Millar; Elizabeth Anderson; Sarah E Clarke; Adam Pennycuick; Ricky M Thakrar; Colin R Butler; Nobuyuki Kakiuchi; Tomonori Hirano; Robert E Hynds; Michael R Stratton; Iñigo Martincorena; Sam M Janes; Peter J Campbell
Journal:  Nature       Date:  2020-01-29       Impact factor: 49.962

7.  Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Authors:  Vitor H Teixeira; Christodoulos P Pipinikas; Adam Pennycuick; Henry Lee-Six; Deepak Chandrasekharan; Jennifer Beane; Tiffany J Morris; Anna Karpathakis; Andrew Feber; Charles E Breeze; Paschalis Ntolios; Robert E Hynds; Mary Falzon; Arrigo Capitanio; Bernadette Carroll; Pascal F Durrenberger; Georgia Hardavella; James M Brown; Andy G Lynch; Henry Farmery; Dirk S Paul; Rachel C Chambers; Nicholas McGranahan; Neal Navani; Ricky M Thakrar; Charles Swanton; Stephan Beck; Phillip Jeremy George; Avrum Spira; Peter J Campbell; Christina Thirlwell; Sam M Janes
Journal:  Nat Med       Date:  2019-01-21       Impact factor: 53.440

8.  Somatic mutant clones colonize the human esophagus with age.

Authors:  Iñigo Martincorena; Joanna C Fowler; Agnieszka Wabik; Andrew R J Lawson; Federico Abascal; Michael W J Hall; Alex Cagan; Kasumi Murai; Krishnaa Mahbubani; Michael R Stratton; Rebecca C Fitzgerald; Penny A Handford; Peter J Campbell; Kourosh Saeb-Parsy; Philip H Jones
Journal:  Science       Date:  2018-10-18       Impact factor: 47.728

9.  Age-related remodelling of oesophageal epithelia by mutated cancer drivers.

Authors:  Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Manabu Muto; Seishi Ogawa; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Ki Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Yoshitaka Nishikawa; Yusuke Amanuma; Shinya Ohashi; Ikuo Aoyama; Takahiro Horimatsu; Shin'ichi Miyamoto; Shigeru Tsunoda; Yoshiharu Sakai; Maiko Narahara; J B Brown; Yoshitaka Sato; Genta Sawada; Koshi Mimori; Sachiko Minamiguchi; Hironori Haga; Hiroshi Seno; Satoru Miyano; Hideki Makishima
Journal:  Nature       Date:  2019-01-02       Impact factor: 49.962

10.  A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.

Authors:  Charles K Kaufman; Christian Mosimann; Zi Peng Fan; Song Yang; Andrew J Thomas; Julien Ablain; Justin L Tan; Rachel D Fogley; Ellen van Rooijen; Elliott J Hagedorn; Christie Ciarlo; Richard M White; Dominick A Matos; Ann-Christin Puller; Cristina Santoriello; Eric C Liao; Richard A Young; Leonard I Zon
Journal:  Science       Date:  2016-01-28       Impact factor: 47.728
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  54 in total

Review 1.  Genetic and non-genetic clonal diversity in cancer evolution.

Authors:  James R M Black; Nicholas McGranahan
Journal:  Nat Rev Cancer       Date:  2021-03-16       Impact factor: 60.716

2.  DLRAPom: a hybrid pipeline of Optimized XGBoost-guided integrative multiomics analysis for identifying targetable disease-related lncRNA-miRNA-mRNA regulatory axes.

Authors:  Chen Shen; Huiyu Li; Miao Li; Yu Niu; Jing Liu; Li Zhu; Hongsheng Gui; Wei Han; Huiying Wang; Wenpei Zhang; Xiaochen Wang; Xiao Luo; Yu Sun; Jiangwei Yan; Fanglin Guan
Journal:  Brief Bioinform       Date:  2022-03-10       Impact factor: 11.622

3.  A heritable, non-genetic road to cancer evolution.

Authors:  Tamara Prieto; Dan A Landau
Journal:  Nature       Date:  2022-01       Impact factor: 49.962

Review 4.  Untangling the web of intratumour heterogeneity.

Authors:  Zheqi Li; Marco Seehawer; Kornelia Polyak
Journal:  Nat Cell Biol       Date:  2022-08-08       Impact factor: 28.213

Review 5.  Mastering the use of cellular barcoding to explore cancer heterogeneity.

Authors:  Antonin Serrano; Jean Berthelet; Shalin H Naik; Delphine Merino
Journal:  Nat Rev Cancer       Date:  2022-08-18       Impact factor: 69.800

Review 6.  Drivers of dynamic intratumor heterogeneity and phenotypic plasticity.

Authors:  Antara Biswas; Subhajyoti De
Journal:  Am J Physiol Cell Physiol       Date:  2021-03-03       Impact factor: 4.249

7.  [Research Progress of Single Cell Sequencing in Lung Cancer].

Authors:  Mengjun Yu; Jinjing Tan; Jinghui Wang
Journal:  Zhongguo Fei Ai Za Zhi       Date:  2021-04-20

8.  Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors.

Authors:  Heba Allah M Alsheikh; Brandon J Metge; Hawley C Pruitt; Sarah C Kammerud; Dongquan Chen; Shi Wei; Lalita A Shevde; Rajeev S Samant
Journal:  Oncogenesis       Date:  2021-06-02       Impact factor: 7.485

9.  Successive High-Resolution (H2O)n-GCIB and C60-SIMS Imaging Integrates Multi-Omics in Different Cell Types in Breast Cancer Tissue.

Authors:  Hua Tian; Louis J Sparvero; Tamil Selvan Anthonymuthu; Wan-Yang Sun; Andrew A Amoscato; Rong-Rong He; Hülya Bayır; Valerian E Kagan; Nicholas Winograd
Journal:  Anal Chem       Date:  2021-06-02       Impact factor: 6.986

Review 10.  Applications of Single-Cell Omics in Tumor Immunology.

Authors:  Junwei Liu; Saisi Qu; Tongtong Zhang; Yufei Gao; Hongyu Shi; Kaichen Song; Wei Chen; Weiwei Yin
Journal:  Front Immunol       Date:  2021-06-09       Impact factor: 7.561
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