Literature DB >> 32805020

TRTools: a toolkit for genome-wide analysis of tandem repeats.

Nima Mousavi1, Jonathan Margoliash2, Neha Pusarla3, Shubham Saini4, Richard Yanicky2, Melissa Gymrek2,4.   

Abstract

SUMMARY: A rich set of tools have recently been developed for performing genome-wide genotyping of tandem repeats (TRs). However, standardized tools for downstream analysis of these results are lacking. To facilitate TR analysis applications, we present TRTools, a Python library and suite of command line tools for filtering, merging and quality control of TR genotype files. TRTools utilizes an internal harmonization module, making it compatible with outputs from a wide range of TR genotypers.
AVAILABILITY AND IMPLEMENTATION: TRTools is freely available at https://github.com/gymreklab/TRTools. Detailed documentation is available at https://trtools.readthedocs.io. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Year:  2021        PMID: 32805020      PMCID: PMC8097685          DOI: 10.1093/bioinformatics/btaa736

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  7 in total

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Authors:  Heng Li
Journal:  Bioinformatics       Date:  2011-09-08       Impact factor: 6.937

Review 2.  Tandem repeats mediating genetic plasticity in health and disease.

Authors:  Anthony J Hannan
Journal:  Nat Rev Genet       Date:  2018-02-05       Impact factor: 53.242

3.  Profiling the genome-wide landscape of tandem repeat expansions.

Authors:  Nima Mousavi; Sharona Shleizer-Burko; Richard Yanicky; Melissa Gymrek
Journal:  Nucleic Acids Res       Date:  2019-09-05       Impact factor: 16.971

4.  Detection of long repeat expansions from PCR-free whole-genome sequence data.

Authors:  Egor Dolzhenko; Joke J F A van Vugt; Richard J Shaw; Mitchell A Bekritsky; Marka van Blitterswijk; Giuseppe Narzisi; Subramanian S Ajay; Vani Rajan; Bryan R Lajoie; Nathan H Johnson; Zoya Kingsbury; Sean J Humphray; Raymond D Schellevis; William J Brands; Matt Baker; Rosa Rademakers; Maarten Kooyman; Gijs H P Tazelaar; Michael A van Es; Russell McLaughlin; William Sproviero; Aleksey Shatunov; Ashley Jones; Ahmad Al Khleifat; Alan Pittman; Sarah Morgan; Orla Hardiman; Ammar Al-Chalabi; Chris Shaw; Bradley Smith; Edmund J Neo; Karen Morrison; Pamela J Shaw; Catherine Reeves; Lara Winterkorn; Nancy S Wexler; David E Housman; Christopher W Ng; Alina L Li; Ryan J Taft; Leonard H van den Berg; David R Bentley; Jan H Veldink; Michael A Eberle
Journal:  Genome Res       Date:  2017-09-08       Impact factor: 9.438

5.  Targeted genotyping of variable number tandem repeats with adVNTR.

Authors:  Mehrdad Bakhtiari; Sharona Shleizer-Burko; Melissa Gymrek; Vikas Bansal; Vineet Bafna
Journal:  Genome Res       Date:  2018-10-23       Impact factor: 9.043

6.  popSTR2 enables clinical and population-scale genotyping of microsatellites.

Authors:  Snædis Kristmundsdottir; Hannes P Eggertsson; Gudny A Arnadottir; Bjarni V Halldorsson
Journal:  Bioinformatics       Date:  2020-04-01       Impact factor: 6.937

7.  Genome-wide profiling of heritable and de novo STR variations.

Authors:  Thomas Willems; Dina Zielinski; Jie Yuan; Assaf Gordon; Melissa Gymrek; Yaniv Erlich
Journal:  Nat Methods       Date:  2017-04-24       Impact factor: 28.547

  7 in total
  6 in total

Review 1.  Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution.

Authors:  Xiao Xiao; Chu-Yi Zhang; Zhuohua Zhang; Zhonghua Hu; Ming Li; Tao Li
Journal:  Mol Psychiatry       Date:  2021-10-14       Impact factor: 15.992

2.  Repeat DNA expands our understanding of autism spectrum disorder.

Authors:  Anthony J Hannan
Journal:  Nature       Date:  2021-01       Impact factor: 49.962

Review 3.  Probably Correct: Rescuing Repeats with Short and Long Reads.

Authors:  Monika Cechova
Journal:  Genes (Basel)       Date:  2020-12-31       Impact factor: 4.096

4.  Combinatorial patterns of gene expression changes contribute to variable expressivity of the developmental delay-associated 16p12.1 deletion.

Authors:  Matthew Jensen; Anastasia Tyryshkina; Lucilla Pizzo; Corrine Smolen; Maitreya Das; Emily Huber; Arjun Krishnan; Santhosh Girirajan
Journal:  Genome Med       Date:  2021-10-18       Impact factor: 15.266

Review 5.  An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data.

Authors:  Tunde I Huszar; Katherine B Gettings; Peter M Vallone
Journal:  Genes (Basel)       Date:  2021-10-29       Impact factor: 4.096

6.  Comprehensive variant calling from whole-genome sequencing identifies a complex inversion that disrupts ZFPM2 in familial congenital diaphragmatic hernia.

Authors:  Thomas J Nicholas; Najla Al-Sweel; Andrew Farrell; Rong Mao; Pinar Bayrak-Toydemir; Christine E Miller; Dawn Bentley; Rachel Palmquist; Barry Moore; Edgar J Hernandez; Michael J Cormier; Eric Fredrickson; Katherine Noble; Shawn Rynearson; Carson Holt; Mary Anne Karren; Joshua L Bonkowsky; Martin Tristani-Firouzi; Mark Yandell; Gabor Marth; Aaron R Quinlan; Luca Brunelli; Reha M Toydemir; Brian J Shayota; John C Carey; Steven E Boyden; Sabrina Malone Jenkins
Journal:  Mol Genet Genomic Med       Date:  2022-02-04       Impact factor: 2.183

  6 in total

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