| Literature DB >> 32802562 |
Seulki Kim1, Dong-Hwa Cho1, Dong-Keon Kweon2, Eun-Hee Jang2, Joo-Yeon Hong2, Seung-Taik Lim1.
Abstract
Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF. © The Korean Society of Food Science and Technology 2020.Entities:
Keywords: Carboxymethyl cellulose; Disintegration time; Low molecular hyaluronic acid; Mechanical properties; Orodispersible film
Year: 2020 PMID： 32802562 PMCID： PMC7406631 DOI： 10.1007/s10068-020-00771-1
Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391