Awareness, Perceptions, and Attitude Regarding Coronavirus Disease 2019 (COVID-19) Among Ophthalmologists in Jordan: Cross-Sectional Online Survey.

PURPOSE: COVID-19 pandemic is a serious public health concern, and the role of health care workers is essential in preventing spread. The study objective is to investigate awareness, perception, and attitude towards COVID-19 and infection control measures among ophthalmologists in Jordan.
METHODS: The design of the study was a cross-sectional survey among Jordanian ophthalmologists. An online survey was sent to 197 ophthalmologists on March 23, 2020. Information on participants' socio-demographic characteristics, knowledge of clinical features of COVID-19, risk assessment and infection control measures for preventing disease transmission, and attitude towards treating patients with COVID-19 were collected.
RESULTS: A total of 132 ophthalmologists (mean age 40.5 years) responded, 23 (17.6%) had received training on infection control in ophthalmology. Most ophthalmologists were aware of COVID-19 symptoms and ways to identify patients at risk of having the disease, correctly reported modes of transmission and were aware of measures for preventing COVID-19 transmission in the ophthalmic setup. Social media was the commonest source of information on COVID-19 (75%), and 38.2% were not provided with instructions on infection control plan to reduce transmission of COVID-19. Most ophthalmologists (79.5%) thought that the virus could be detected in tears, and 72.2% thought that red eye as a symptom of COVID-19.
CONCLUSION: Ophthalmologists in Jordan were aware of the epidemiology of COVID-19 and related infection preventive measures. Knowledge was lacking regarding ocular aspects of the disease. Training on infection prevention needs to be improved. Access to guidelines from international ophthalmological organizations should be promoted and seeking updated literature from peer-reviewed journals needs to be encouraged.

Introduction

According to the World Health Organization (WHO), coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, officially named as ‘severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease started as a pneumonia of unknown cause in Wuhan, China, in December 2019,1 and was declared by the WHO as public health emergency of international concern.2 It is a global health threat, as there have been 8,242, 999 cases confirmed worldwide3 as of June 18, 2020. In Jordan, there are currently 981 confirmed cases4 compared to 246 cases at the time the survey was conducted. The incubation period for COVID 19 is up to 14 days, with a median of 5 days.5

The virus spreads mainly from person to person through droplets contact with mucus membrane.6 It is also possible to spread via direct contact with a contaminated surface. Presumed asymptomatic carrier transmission of COVID-19 has been reported7,8. The virus is considered to be highly pathogenic and transmissible.9 Common symptoms include fever, cough, and fatigue.10 Several reports suggested that it can cause conjunctivitis in up to 30% of cases,11,12 in addition to that being isolated from conjunctival secretions. One case report found that viral RNA was detectable in ocular swabs many days after it was undetectable in nasal swabs.13 Angiotensin-converting enzyme 2 (ACE2) receptor and host cell transmembrane protease, serine 2 (TMPRSS2) are implicated in the process of viral attachment and interaction with ocular surface cells.14 This has led to a discussion on the possibility of SARS-CoV-2 being transmitted to a person via the conjunctival route15–18 This remains a controversial issue but the possibility of conjunctival transmission must not be ignored.19

Health care workers are at increased risk of contracting COVID-19, and their safety is needed for the continuous provision of medical care of COVID-19 patients as well as preventing the transmission of the virus to other individuals.20 Ophthalmologists and other eye care providers are no exception to this, and they are particularly vulnerable. Sources of infection include droplet infection and to a lesser extent, touching contaminated instruments and objects. Because of the proximity (less than 1 meter) to the patient during slit-lamp examination or ophthalmoscopy, transmission of infection from an asymptomatic patient is a serious issue, considering that most COVID-19 patients are either asymptomatic or mildly affected. Furthermore, the possible presence of the virus in tears can inadvertently contaminate both the examiner and examination equipment.21

Ophthalmic patients are also at increased risk of COVID-19. Many of them are elderly patients with reduced immunity. Diabetes and hypertension among such patients appear to increase the severity and complications of COVID-19.22 Ocular examination is particularly lengthy and requires that many patients stay for 15–30 minutes, usually in a crowded waiting area, in addition to excessive mobilization between different examination stations. This prolongs exposure time to possible airborne virus and increases the risk of spreading the infection to other patients and health care staff. Certain ophthalmic tests have been found to disrupt the tear film and cause microaerosol formation such as when performing noncontact “air-puff” tonometry.23 In view of the high infectivity of SARS-CoV-2, this may pose a real risk to all those present in the test area.

Many official international ophthalmologic organizations are continuously issuing updated clinical guidelines on COVID-19, detailing how to deal with the current COVID-19 situation.24,25 They focus mainly on educating ophthalmologists on COVID-19, detecting and stratifying at risk patients, dealing with each category, cutting or cancelling routine clinic visits, and nonurgent surgery, stressing the use of personal protection equipment (PPE), and adherence to proper disinfection methods. A helpful decision tree to facilitate the implementation of current guidelines in the ophthalmic setup is described by Gharebaghi.26 The objective of this study is to investigate the level of awareness, perception, and attitude about COVID-19 and infection control measures among ophthalmologists in Jordan.

Materials and Methods

Study Population

The study population consisted of ophthalmology specialists and residents in their final year, practicing in Jordan. Four sectors were included: The Ministry of Health, the Royal Medical Services, the academic/university, and the private sector. The study was conducted on 23 March 2020 and the survey was available to participate in for a period of 2 days. A web-based survey using Google forms was constructed to collect data. Certain questions were derived from another survey related to dentists in Jordan.27 The sample of ophthalmologists was selected by asking a representative of each sector to disseminate the invitation to participate in the survey via a social media messaging application. A total of 197 ophthalmology doctors were selected based on their sector affiliation.

The survey was designed to ensure confidentiality of the information collected and the anonymity of all the study participants. The study was conducted according to the Helsinki Declaration principles. Ethical approval was obtained from the Institutional Review Board at Jordan University of Science and Technology. The ophthalmologists’ participation and completion of the survey was regarded to be an informed consent to the study.

Study Instrument

After reviewing relevant literature and guidelines from two major official international ophthalmological organizations,24,25,28 a survey containing 35 multiple choice questions was constructed and written in English. The questions covered four major areas: 1) socio-demographic and professional characteristics, 2) level of awareness of clinical features (incubation period, symptoms of the disease, mode of transmission), 3) risk assessment of COVID-19 and infection control measures for preventing COVID-19 transmission, and 4) perception and attitude towards treating patients under different settings, related to COVID-19. The questions in the survey are available in .

Data Analysis

Data were analysed using IBM SPSS version 24. Descriptive statistics were used to describe items included in the survey. Means and standard deviations were used to describe the continuous variables and percentages were used to describe the categorical data.

Results

A total of 132 (100 males and 32 females) ophthalmology doctors out of 197 (67%) completed the study survey. The mean (SD) age of participants was 40.5 (9.6) years (range: 27–68 years). Almost one-third (48,36.4%) were working at the Royal Medical Services, followed by 41 (31.1%) at the private sector, 23 (17.4%) at the Ministry of Health, and 20 (15.2%) at academic/university institutions.

The participants’ demographic and professional characteristics are shown in Table 1. The majority (122, 92.4%) of participants were either board certified or eligible and 10 (7.6%) were senior residents, 23 (17.6%) received training on infection control in ophthalmology, and 26 (19.7%) attended lectures or training on COVID-19. The mean (SD) clinical ophthalmic experience was 12.7 (8.9) years.

Table 1

The Participants’ Demographic and Professional Characteristics

Variable	n	%
Gender
Male	100	75.8
Female	32	24.2
Age category
≤35	47	35.9
36–40	32	24.4
>40	52	39.7
Experience in years
≤10	69	52.3
>10	63	47.7
Sector
Academic/University sector	20	15.2
Ministry of Health	23	17.4
Private sector	41	31.1
Royal Medical Services	48	36.4

Sources of Information on COVID-19

Regarding information on COVID-19 pertaining to ophthalmologists, 99 (75%) doctors said they received information through social media websites and applications, and 21 (15.9%) through the Jordanian Ophthalmological Society. Table 2 shows the sources of information on COVID-19.

Table 2

The Sources of Information on Coronavirus Disease 2019 (COVID-19) Reported by the Participants

	n	%
Social media	99	75.0
Google search	82	62.1
E-mail newsletters from official organizations	68	51.5
Local hospital	31	23.5
Peer-reviewed journals	30	22.7
Jordanian Ophthalmological Society	21	15.9

Awareness of Clinical Features of COVID-19

Regarding the incubation period, 93 (70.5%) doctors reported 2–14 days. When asked about symptoms of COVID-19, fever and cough were reported by 131 (99.1%) of ophthalmologists. Red eye was reported by 96 (72.2%) doctors, and 116 (87.9%) stated it may present with no symptoms. Other symptoms as reported by the participants are shown in Table 3.

Table 3

Symptoms of Coronavirus Disease 2019 (COVID-19) Reported by Participants

Symptoms	n	%
Fever	131	99.2
Cough	131	99.2
Shortness of breath	129	97.7
May present with no symptoms	116	87.9
Sore throat	104	78.8
Red eye	96	72.7
Diarrhea	83	62.9
Joint/muscle pain	74	56.1
Runny nose	48	36.4
Vomiting	47	35.6
Skin rash	12	9.1

Most doctors were able to identify common modes of transmission (Table 4). However, 109 (82.6%) ophthalmologists considered finger contact with patients’ tears and aerosol contamination to the conjunctiva as modes of transmission.

Table 4

Modes of Transmission Reported by Participants

Mode of Transmission	n	%
Hand shaking	131	99.2
Touching surfaces (slit lamps and tables)	131	99.2
Coughing and sneezing	126	95.5
Finger contact with patients’ tears	109	82.6
Aerosol contamination to the conjunctiva	109	82.6

Awareness of Risk Assessment and Prevention of COVID-19 Transmission

More than 85.6% of doctors reported the following to identify patients at risk of having COVID-19 infection: history of travel to high-risk areas of COVID-19, history of contact with possible infected patients, and presence of fever and presence of symptoms of a respiratory infection. Presence of acute conjunctivitis was reported by 56 (42.4%) as indicative of a risk.

Whether patients attending for eye clinic appointments were at higher risk of contracting COVID-19, 78 (59.1%) ophthalmologists answered yes, 28 (21.2%) answered no, and 26 (19.7%) did not know. Most doctors (95, 72%) reported that the virus could be detected in tears, and (105, 79.5%) reported that COVID-19 can be transmitted by aerosol contact with conjunctiva. However, 122 (92.4%) agreed that the virus is very likely susceptible to the same alcohol- and bleach-based disinfectants that ophthalmologists commonly use to disinfect ophthalmic instruments and clinic furniture. Most doctors (130,98.5%) reported that COVID-19 can be transmitted from an asymptomatic carrier to an ophthalmologist during routine eye exam. However, 78 (59.1%) reported that they routinely used a slit lamp microscope with no clear plastic shield mounted on it. Table 5 shows the responses regarding measures that should be taken to prevent COVID-19 transmission in the ophthalmic examination room.

Table 5

Participants Responses Regarding Measures That Should Be Taken to Prevent COVID-19 Transmission in the Ophthalmic Examination Room

	n	%
Frequently clean hands by using alcohol-based hand rub or soap and water	130	99.2
Routinely clean and disinfect surfaces in contact with known or suspected patients	129	98.5
Put facemask on known or suspected patients	128	97.7
Avoid moving and transporting patients out of their area unless necessary	121	92.4
All health staff members wear protective clothing	113	86.3
Place known or suspected patients in adequately ventilated single rooms	106	80.9
Taking Multivitamins to boost immunity	59	45.0

Attitude Towards Managing COVID-19 Patients/Suspects

Before listing patients in the clinic, doctors reported they would adopt the following measures: 122 (92.4%) would ask the patient to bring no more than one accompanying person if necessary, 118 (89.4%) would enquire if the patient or a family member has traveled to a high-risk area in the past 14 days, 116 (87.9%) would reduce the total number of appointments in one day, 113 (85.6%) would avoid listing more than one patient at the same time, and 107 (81.1%) would ask the patient not to attend if they have cough or sore throat.

At the examination room, most doctors (130,98.5%) believe that distancing patients far from each other, asking patients to wear masks in the waiting room, and applying alcohol to patients’ hands helps to reduce disease transmission, while only 2 (1.5%) doctors disagreed with the above measures as they may cause unnecessary anxiety.

Of those doctors working at clinics outside a hospital, 59 (79.7%) doctors agreed to treat the patient who has cough after taking extra precautions and then ask the patient to be seen at a hospital for their symptoms, 5 (6.8%) would refer the patient to the hospital without treating him/her, and 10 (13.5%) would refuse treating the patient and ask him/her to leave the clinic. When asked to see an urgent case with no symptoms or risk factors for COVID-19, 59 (45%) doctors reported that standard precautions that apply to all patient care is enough, 105 (80.2%) reported that minimizing speech between the patient and the examiner during slit-lamp examination is appropriate, whereas 30 (22.9%) thought that mask, gown and gloves are not routinely required for either the patient or doctor. When asked to see an urgent case with respiratory illness symptoms, but no fever or other COVID-19 risk factor, most doctors (108, 81.8%) reported that they will require that patients and clinicians wear masks, 90.2% recommended using gloves and proper eye protection, and 84.8% reported that examining room must be cleaned after examination.

In the case of a confirmed COVID-19 patient presenting to an outpatient clinic as an urgent case, 48 (36.4%) doctors said they work at a public hospital and would follow its policy, 57 (43.2%) would send the patient to a hospital equipped to deal with COVID-19 and urgent eye conditions, and 27 (20.5%) would take all necessary precautions and treat the patient. Overall, 106 (80.3%) doctors reported that they prefer to avoid encountering or examining a patient who is a suspect of COVID-19, and 117 (88.6%) doctors reported that they would not permit their optician to examine patients with symptoms of respiratory tract infection.

Perception of COVID-19

COVID-19 was perceived as very dangerous by 74 (56.1%) doctors, moderately dangerous by 56 (42.4%), and not dangerous by only 2 (1.5%) doctors. Nevertheless, nearly two-thirds (91, 68.9%) agreed that symptoms often resolve with time and do not require any special treatment. All the participants agreed that the ophthalmologist role in teaching others about COVID-19 is significant. The participants expressed different opinions regarding the option to run their clinics with local health authority’s permission. Nearly half of them (64, 48.5%) would accept only urgent cases, 12 (9.1%) would see all routine cases provided they are low risk (no symptoms or travel), 8 (6.1%) preferred not seeing patients at all, and 48 (36.4%) work at public hospitals and would therefore, follow the hospital’s policy.

Preparedness

When asked if a clear strategy/infection control plan to reduce transmission of COVID-19 between patients or to ophthalmologists at the eye clinic was provided by the hospital/employing authority, more than one-third (50, 38.2%) were not provided with such a plan, 29 (22.1%) were given general verbal instructions, 25 (19.1%) implemented a clear plan, and 16 (12.2%) were given only written instructions to cancel routine consultations and surgeries, but no instructions on infection control measures. Eleven (8.4%) doctors preferred not to answer.

Discussion

In this survey, a relatively acceptable response rate of 67% was attained. A small percentage of respondents had previous training in infection control in ophthalmology or attended lectures regarding COVID-19, and nearly 60% of them reported either being given no instructions, or just verbal instructions on dealing with current COVID-19 situation. Even though most ophthalmologists had shown good knowledge on preventive measures and infection control, this was a personal effort, and may explain why most doctors reported that the source of information they receive regarding COVID-19 was social media. This presents potential risks to patients and doctors related to information quality, patients' privacy, and potential legal issues. Guidelines on the use of social media for health care providers have been issued by many professional organizations worldwide, the objective of which is to provide proper advice on the use of such media and reduce the chances of committing professional mistakes when using or resorting to such media.29 Ophthalmologists are advised to make all efforts to ensure the information they derive come from credible and official sources. The educational role of local infection control committee is more informative, concise, relevant, and updated. Regular meetings to discuss updates and new emerging issues in infection control, and the inclusion of such measures in the residency curriculum may help ophthalmologists to be better prepared for possible outbreaks in the future. Clear and written plans for dealing with COVID-19, when circulated to all staff, can contribute to better and faster preparation in such situations.

The least used source of information obtained was from the Jordanian Ophthalmological Society. This highlights the need for the national societies to adopt a more active role during this emergency to deliver appropriate information on the current pandemic and evidence-based guidelines. Such guidelines could be derived and adapted from the continuously updated American Academy of Ophthalmology24,28 and the Royal College of Ophthalmologists25 websites.

Most doctors identified the correct incubation period of 2–14 days, which helps define high risk/suspect patients who can be safely treated. However, as incubation periods of more than 14 days were recently reported,30 it might be wiser to practice extra precautions with suspected patients even after 14 days.

Common symptoms were identified correctly by most doctors, a key factor in identifying suspect patients. Interestingly, red eye was reported by 70% of ophthalmologists. However, a study of 1099 patients with COVID-19 reported by Guan et al showed that only 0.8% of the patients presented with red eye.31 This finding might be explained by the ophthalmologists’ awareness of the common association of conjunctivitis with common respiratory virus infections.32 They were also able to identify common modes of transmission including the possibility of asymptomatic transmission. However, 82.6% thought that finger contact with patient’s tears and aerosol contamination to the conjunctiva as a mode of transmission. This response is possibly due to ophthalmologists’ awareness of the high rate of transmission via tears in adenovirus conjunctivitis, a common entity in ophthalmic practice.33 The rapidly emerging evidence regarding this issue is still unresolved, and most evidence so far is against the possibility of conjunctival or tear transmission.15,34,35 Nevertheless, most participants appear to assume that possibility and would therefore be more careful when examining patients’ eyes.

Ophthalmologists’ knowledge of measures to prevent transmission of COVID-19 was generally in accordance with the guidelines of the American Academy of Ophthalmology, which includes instructions on triaging patients attending the eye clinic, identifying high-risk patients, social distancing of patients, and minimizing speech during the examination. The lack of a clear plastic barrier on slit lamp microscope as reported by more than half of respondents can pose extra risk during patient examination, and the AAO clearly advises the use of such shields and that doctors need to protect their mouth, nose (e.g., an N-95 mask) and eyes (e.g., goggles or shield) when caring for patients potentially infected with COVID-19.24,28 The AAO also stresses the proper cleaning and disinfection of examination rooms and equipment using different types of disinfectants. A recent review36 suggested that surface disinfection with 0.1% sodium hypochlorite or 62–71% ethanol significantly reduces coronavirus infectivity on surfaces within 1 min exposure time and that a similar effect against the SARS-CoV-2 is expected. Most ophthalmologists in the survey identified the efficiency of the above disinfectants against the virus.

The attitude of ophthalmologists towards managing low risk, suspected or confirmed COVID-19 patients was also in line with the AAO guidelines. Most doctors reported they would follow certain measures before listing patients at the clinic, the purpose of which is to reduce the number of persons present at any time and to triage and exclude COVID-19 suspects.

When ophthalmologists were asked of what to do when they are assessing patients and a patient starts to cough while in the waiting room, all participants reported either not examining patients or examining them with extra precautions. Regarding these low-risk COVID-19 cases, the AAO recommends wearing a gown, surgical mask and eye protection, and to use N95 mask when a surgical procedure that will result in aerosol production is carried out, in addition to disinfection of the examination room. Most participants reported they would follow the same recommendations.

Contrary to AAO and other international guidelines, an alarming 20% of doctors reported they would treat urgent confirmed COVID-19 cases on outpatient basis after taking precautions. The AAO guidelines include managing such patients at a hospital-based setting that is equipped to manage both COVID-19 and eye conditions.

Almost two-third of doctors reported that most COVID-19 symptoms would resolve with no treatment. Yet, the disease was perceived as dangerous by most participants. This may be indicative of the ophthalmologists’ awareness that the seriousness of COVID-19 epidemic lies in its ability to overwhelm the health care system,37 where in many cases, patients with urgent ophthalmic conditions become at risk of not obtaining proper timely care.

Being part of the medical community, most ophthalmologists agreed on their role in educating patients about COVID-19, to effectively reduce transmission and promote health.

One limitation of this study is that the survey was administered in English, which may constitute a language barrier to fully understand the questions by some respondents. In addition, the participants gave many responses regarding their source of information on COVID-19, which precluded knowing the primary or preferred source. Knowing this source might enable further assessment of the reliability and suitability of such source and give better advice on its use by ophthalmologists. One should consider that this study assessed awareness and perception of ophthalmologists regarding COVID-19 and it does not reflect their real practice as none of the ophthalmologists has treated any patients with COVID-19 yet.

In conclusion, ophthalmologists in Jordan were aware of different aspects related to COVID-19 including the incubation period, symptoms, mode of transmission, and infection preventive measures at the ophthalmic setup, but knowledge was lacking regarding ocular characteristics of the disease. Training on infection prevention and control needs to be stressed. Access to high-quality guidelines from international professional ophthalmological organizations should be promoted through the national ophthalmological society and seeking updated literature from peer-reviewed journals should be encouraged and disseminated.