Literature DB >> 3280138

Site-specific endonucleolytic cleavages and the regulation of stability of E. coli ompA mRNA.

O Melefors1, A von Gabain.   

Abstract

The stability of ompA mRNA is growth-rate dependent. We show that the 5' noncoding region of this mRNA provides a target for site-specific endonucleases. The rate of degradation of ompA mRNA parallels the rate of these endonucleolytic cleavages, implying that endonucleolytic rather than exonucleolytic attack is the initial step in ompA mRNA degradation. Thus the 5' noncoding region appears to be a determinant of mRNA stability, and endonucleolytic cleavages in the 5' noncoding region may well regulate expression of the ompA gene.

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Year:  1988        PMID： 3280138     DOI： 10.1016/0092-8674(88)90431-x

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  66 in total

1.  Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding.

Authors:  O Vytvytska; I Moll; V R Kaberdin; A von Gabain; U Bläsi
Journal:  Genes Dev       Date:  2000-05-01       Impact factor: 11.361

2.  Probing the substrate specificity of Escherichia coli RNase E using a novel oligonucleotide-based assay.

Authors:  Vladimir R Kaberdin
Journal:  Nucleic Acids Res       Date:  2003-08-15       Impact factor: 16.971

3.  FNR-mediated oxygen-responsive regulation of the nrdDG operon of Escherichia coli.

Authors:  T Boston; T Atlung
Journal:  J Bacteriol       Date:  2003-09       Impact factor: 3.490

4.  Processing in the 5' region of the pnp transcript facilitates the site-specific endonucleolytic cleavages of mRNA.

Authors:  R Takata; M Izuhara; K Akiyama
Journal:  Nucleic Acids Res       Date:  1992-02-25       Impact factor: 16.971

5.  Antirepression function in Escherichia coli for the cAMP-cAMP receptor protein transcriptional activator.

Authors:  K Forsman; B Sondén; M Göransson; B E Uhlin
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

6.  Degradation products of the mRNA encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean and transgenic petunia.

Authors:  D M Thompson; M M Tanzer; R B Meagher
Journal:  Plant Cell       Date:  1992-01       Impact factor: 11.277

7.  Novel role for RNase PH in the degradation of structured RNA.

Authors:  Chaitanya Jain
Journal:  J Bacteriol       Date:  2012-05-18       Impact factor: 3.490

8.  Novel transcriptional control of the pyruvate formate-lyase gene: upstream regulatory sequences and multiple promoters regulate anaerobic expression.

Authors:  G Sawers; A Böck
Journal:  J Bacteriol       Date:  1989-05       Impact factor: 3.490

9.  Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus.

Authors:  L Janzon; S Löfdahl; S Arvidson
Journal:  Mol Gen Genet       Date:  1989-11

10.  mRNA stabilizing signals encoded in the genome of the bacteriophage phi x174.

Authors:  M N Hayashi; R Yaghmai; M McConnell; M Hayashi
Journal:  Mol Gen Genet       Date:  1989-04
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