Xiao Zhang1, Mengxue Chen1, Ruonan Duan1, Hongmei Xue2,3, Jiao Luo2, Xiaohua Lv2, Hong Jia4, Fang He2, Lishi Zhang2, Guo Cheng5,6. 1. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, PR China. 2. West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, PR China. 3. College of Public Health, Hebei University, Baoding, PR China. 4. Department of Epidemiology and Biostatistics, School of Public Health, Southwest Medical University, Luzhou, PR China. 5. Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, PR China. gcheng@scu.edu.cn. 6. West China School of Nursing, Sichuan University, Chengdu, Sichuan, PR China. gcheng@scu.edu.cn.
Abstract
BACKGROUND: There are few studies of nutritional and genetic factors and their interactions on the risk of noncommunicable diseases (NCDs) among Chinese adults. OBJECTIVE: Our aim for the Nutrition and Health in Southwest China (NHSC) study is to investigate the impact of diet, lifestyle, genetic background, and their interactions on NCDs among adults in Southwest China. METHODS: The NSHC is a prospective cohort study initiated in winter 2013. The baseline data collection was completed in December 2018, and follow-ups are conducted every 2 years. Information on genomics, anthropometry, nutrition, eating behaviors, physical activity, depression and mental disorders, clinical and biochemical examinations, and lifestyles was collected. RESULTS: 7926 adults completed the baseline questionnaire. The average age of participants was 42.6 (9.8) years at study enrollment. More than half were female, 37.2% had achieved more than 12 years of education, and 49.3% of them came from family income >35,000 Yuan. Our analyses of the baseline data suggested that adults with greater dietary energy density appeared to have greater body mass index, fat mass index, fat-free mass index and percentage body fat, and that participants with a higher level of dietary glycemic index, glycemic load, or serum 25(OH)D had a less favorable glucose homeostasis. In addition, spending less time watching television and having a healthy eating pattern may play significant roles in later cellular aging. CONCLUSIONS: In conclusion, the NHSC cohort provides valuable data for investigations of the relevance of gene, nutrition, lifestyles, and their interactions on NCDs among southwestern Chinese adults.
BACKGROUND: There are few studies of nutritional and genetic factors and their interactions on the risk of noncommunicable diseases (NCDs) among Chinese adults. OBJECTIVE: Our aim for the Nutrition and Health in Southwest China (NHSC) study is to investigate the impact of diet, lifestyle, genetic background, and their interactions on NCDs among adults in Southwest China. METHODS: The NSHC is a prospective cohort study initiated in winter 2013. The baseline data collection was completed in December 2018, and follow-ups are conducted every 2 years. Information on genomics, anthropometry, nutrition, eating behaviors, physical activity, depression and mental disorders, clinical and biochemical examinations, and lifestyles was collected. RESULTS: 7926 adults completed the baseline questionnaire. The average age of participants was 42.6 (9.8) years at study enrollment. More than half were female, 37.2% had achieved more than 12 years of education, and 49.3% of them came from family income >35,000 Yuan. Our analyses of the baseline data suggested that adults with greater dietary energy density appeared to have greater body mass index, fat mass index, fat-free mass index and percentage body fat, and that participants with a higher level of dietary glycemic index, glycemic load, or serum 25(OH)D had a less favorable glucose homeostasis. In addition, spending less time watching television and having a healthy eating pattern may play significant roles in later cellular aging. CONCLUSIONS: In conclusion, the NHSC cohort provides valuable data for investigations of the relevance of gene, nutrition, lifestyles, and their interactions on NCDs among southwestern Chinese adults.
Authors: Jingyuan Xiong; Yujie Xu; Xueting Liu; Xiaoyu Wang; Shufang Shan; M James C Crabbe; Li Zhao; He Fang; Guo Cheng Journal: BMC Med Date: 2022-04-04 Impact factor: 8.775